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Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis
- Source :
- Biomarkers in medicine, 9(12), 1301-1309. FUTURE MEDICINE LTD, Biomarkers in Medicine, 9(12), 1301-1309. Future Medicine Ltd.
- Publication Year :
- 2015
-
Abstract
- Aim: Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by lipid accumulation and inflammation. Here, we aimed to evaluate plasma IL-1Ra as a marker for NASH and to determine whether diagnosis of NASH can be further improved by adding IL-1Ra measurements. Materials & methods: Therefore, plasma concentrations of IL-1Ra were measured from 146 subjects of a biopsy-proven NASH cohort with matched controls. Results: NASH patients had higher levels of plasma IL-1Ra compared with patients with steatosis or healthy controls. Conclusion: Our data confirm that IL-1Ra can be a useful tool in the diagnosis of hepatic inflammation and suggest that measuring plasma IL-1Ra levels in addition to ALT will improve the diagnosis for NASH at all stages of the disease.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.drug_class
diagnosis
Clinical Biochemistry
Inflammation
Disease
digestive system
Liver disease
Non-alcoholic Fatty Liver Disease
Internal medicine
NAFLD
Drug Discovery
medicine
Humans
FATTY LIVER-DISEASE
hepatic inflammation
business.industry
Biochemistry (medical)
Case-control study
NASH
nutritional and metabolic diseases
Middle Aged
medicine.disease
Receptor antagonist
CYTOKERATIN-18
digestive system diseases
Interleukin 1 Receptor Antagonist Protein
MICE
Endocrinology
IL-1Ra
Liver
ROC Curve
Case-Control Studies
OBESITY
Cohort
Female
Steatosis
medicine.symptom
Steatohepatitis
business
Subjects
Details
- Language :
- English
- ISSN :
- 17520363
- Volume :
- 9
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Biomarkers in Medicine
- Accession number :
- edsair.doi.dedup.....713ce8d9f7598bcc3a1ea9e836fe835e