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The contribution of human leucocyte antigen complex genes to disease phenotype in ulcerative colitis
- Publication Year :
- 2016
-
Abstract
- Linkage and association studies implicate the human leucocyte antigen (HLA) region in genetic susceptibility to ulcerative colitis (UC). However, associations with specific variants have been inconsistent, even within defined ethnic groups. A genetic basis for the disease heterogeneity of UC may account for these discrepant findings from studies in unselected populations. Here, we examine the contribution of the HLA region to the clinical phenotype of UC. We studied 321 accurately phenotyped patients recruited from a single UK centre, with a median follow-up time of 15 years. Individuals were genotyped for 340 polymorphisms constructed into 25 gene-specific allelic haplotypes between HLA-A and Tapasin. Data were analysed with respect to age of onset, disease extent and severity. Strongest association with overall susceptibility was identified with HLA-DRB1 alleles replicating previous studies (DRB1*0103, DRB1*1502 and DRB1*0401). We report a novel association with homozygosity of a tumour necrosis factor (TNF) promoter haplotype (TNF-1031T, -863C, -857C, -380G, -308G and -238G) and distal disease extent that does not extend with time (distal vs total 40.9 vs 25.7%; RR = 2.0; 95% CI 1.23-3.24). We confirm the association of DRB1*0103 with total disease and/or disease requiring colectomy and further demonstrate that DRB1*0103 is associated with shorter time to surgery. Genes in the HLA play a role in modifying disease phenotype. Further studies are required to dissect how these genes functionally interact with each other and with environmental factors to determine clinical patterns of disease
- Subjects :
- Adult
Male
Adolescent
Immunology
Disease
Human leukocyte antigen
Biology
Polymorphism, Single Nucleotide
Biochemistry
Cohort Studies
Major Histocompatibility Complex
HLA Antigens
Genetics
Genetic predisposition
medicine
Humans
Immunology and Allergy
Genetic Predisposition to Disease
Age of Onset
Allele
Child
Aged
Genetic association
Haplotype
Infant, Newborn
Infant
General Medicine
Middle Aged
medicine.disease
Ulcerative colitis
Phenotype
Haplotypes
Colitis, Ulcerative
Female
Age of onset
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....7118a707b00c2e5cb65546debd2785e7