Back to Search
Start Over
[Salivary cortisol testing: preanalytic and analytic aspects]
- Source :
- Annales de biologie clinique. 76(4)
- Publication Year :
- 2018
-
Abstract
- Salivary cortisol assay, described for the first time almost forty years ago, has not been expanding until the last decade. Its simplicity, non-invasiveness and the easy repetition of sampling make it an analytical matrix of interest. Since the publication of the recommendations of the American endocrinology society in 2008, salivary cortisol is recognized as one of the three main tests to screen for Cushing's syndrome. In addition, salivary cortisone, the major metabolite of salivary cortisol, still represents a severe potential interferent but could also be a complementary analyte for indications where evaluation of cortisol secretion is sought. Moreover, in the current context of practices and methods harmonization, the problem of lack of standardization presents also for salivary cortisol. This review briefly develops the three main tests of Cushing's syndrome screening to explain the reasons for integrating the saliva test into this screening. Then we will develop the variables that can influence salivary cortisol from a pre-analytic, physiopathological and finally analytical point of view.
- Subjects :
- Cortisol secretion
Hydrocortisone
business.industry
Pre-Analytical Phase
030209 endocrinology & metabolism
Context (language use)
General Medicine
Circadian Rhythm
Specimen Handling
03 medical and health sciences
0302 clinical medicine
Addison Disease
Saliva testing
medicine
Humans
Cortisone
business
Saliva
Cushing Syndrome
030217 neurology & neurosurgery
Salivary cortisol
medicine.drug
Clinical psychology
Subjects
Details
- Language :
- French
- ISSN :
- 19506112
- Volume :
- 76
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Annales de biologie clinique
- Accession number :
- edsair.doi.dedup.....7113235fffe7e9a99f09e94c484a5bda