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Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective
- Source :
- International Journal of Molecular Sciences, Vol 23, Iss 682, p 682 (2022), International Journal of Molecular Sciences
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- The retinal pigmented epithelium (RPE) plays a pivotal role in retinal homeostasis. It is therefore an interesting target to fill the unmet medical need of different retinal diseases, including age-related macular degeneration and Stargardt disease. RPE replacement therapy may use different cellular sources: induced pluripotent stem cells or embryonic stem cells. Cells can be transferred as suspension on a patch with different surgical approaches. Results are promising although based on very limited samples. In this review, we summarize the current progress of RPE replacement and provide a comparative assessment of different published approaches which may become standard of care in the future.
- Subjects :
- induced pluripotent stem cells
QH301-705.5
age related macular degeneration
Review
Retinal Pigment Epithelium
replacement
Catalysis
Translational Research, Biomedical
Inorganic Chemistry
Macular Degeneration
Humans
Physical and Theoretical Chemistry
Biology (General)
Molecular Biology
QD1-999
Spectroscopy
Clinical Trials as Topic
Ophthalmologists
retinal pigmented epithelium
Organic Chemistry
General Medicine
embryonic stem cells
eye diseases
Computer Science Applications
Stargardt disease
Chemistry
sense organs
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 23
- Issue :
- 682
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....70f21d819f8afb12806a7359c1d39d64