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Bone Filling Around Titanium Implants May Benefit From Smoking Cessation: A Histologic Study in Rats
- Source :
- Journal of Periodontology. 76:1476-1481
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- Although a harmful effect of smoking on titanium implants has been documented, only a few studies have investigated the benefits of smoking cessation. Thus, this study histologically investigated whether smoking cessation influences bone healing around titanium implants and comparatively evaluated temporary versus complete cessation protocols.Sixty-six male Wistar rats were randomly assigned to one of four groups: control (N = 16); CSI, intermittent cigarette smoke inhalation (CSI) throughout the entire 150-day experiment (N = 17); P-CSI, CSI 83 days prior to implant placement (N = 17); or R-CSI, CSI for 83 days, cessation 7 days before and 21 weeks after implant placement, and return to CSI for 39 days (N = 16). The animals were sacrificed and the degree of bone-to-implant contact (BIC) and the bone area (BA) within the limits of the implant threads obtained for cortical (zone A) and cancellous bone (zone B).Intergroup analysis (Kruskal-Wallis test, alpha = 0.05) demonstrated a significant effect of CSI on BA (P0.05) and that temporary or complete CSI cessation protocols resulted in values similar to those of the control group (P0.05) 88.91% +/- 4.29%; 80.66% +/- 6.55%; 84.27% +/- 6.96%; 85.71% +/- 4.7% in zone A, and 51.28% +/- 6.49%; 38.69% +/- 10.78%; 48.87% +/- 8.47%; 49.47% +/- 8.04%; in zone B for groups CTRL, CSI, P-CSI, and R-CSI, respectively.Within the limits of the present investigation, temporary and complete CSI cessation reversed the effect of smoke exposure on bone healing around titanium implants in both cortical and cancellous bone.
- Subjects :
- Male
medicine.medical_treatment
Dentistry
chemistry.chemical_element
Bone healing
Osseointegration
Random Allocation
Osteogenesis
medicine
Animals
Rats, Wistar
Dental Implants
Titanium
Inhalation
business.industry
Smoking
Smoke exposure
Rats
medicine.anatomical_structure
chemistry
Periodontics
Smoking cessation
Smoking Cessation
Implant
business
Cancellous bone
Subjects
Details
- ISSN :
- 19433670 and 00223492
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- Journal of Periodontology
- Accession number :
- edsair.doi.dedup.....70ca499d3e141091b40d74a7339ae5a5