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Origin of Gliomas
- Source :
- Seminars in Neurology. 38:005-010
- Publication Year :
- 2018
- Publisher :
- Georg Thieme Verlag KG, 2018.
-
Abstract
- Malignant glioma is a common type of brain tumor that remains largely incurable. Although a definitive cell of origin of gliomas remains elusive, numerous population studies, sequencing efforts, and genetically engineered mouse models have contributed to our understanding of the early events that may lead to gliomagenesis. Herein we summarize our current knowledge on the population epidemiology of gliomas, heritable genetic risk factors, the somatic events that contribute to tumor evolution, and mouse models that have shed light on the glioma cell of origin. Future studies will increase our understanding of the sequence of early events within susceptible cells and their niche that trigger the path to malignant transformation. Such knowledge will allow us to design more effective treatment options to control tumor growth or screening methods for early detection.
- Subjects :
- 0301 basic medicine
education.field_of_study
Brain Neoplasms
business.industry
Somatic cell
Cell of origin
Population
Brain tumor
Glioma
medicine.disease
Malignant transformation
Review article
03 medical and health sciences
030104 developmental biology
Neurology
Genetically Engineered Mouse
medicine
Cancer research
Animals
Humans
Neurology (clinical)
education
business
Subjects
Details
- ISSN :
- 10989021 and 02718235
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Seminars in Neurology
- Accession number :
- edsair.doi.dedup.....70b98246c4dfd1e2598c12e62b4bdadb