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FK506 increases the regeneration of spinal cord axons in a predegenerated peripheral nerve autograft
- Source :
- The journal of spinal cord medicine. 22(4)
- Publication Year :
- 2000
-
Abstract
- The authors examined the ability of FK506 to accelerate axonal regeneration of rat spinal cord axons in a peripheral nerve (PN) graft. Predegenerated autografts were produced by transecting the left tibial nerve 1 week prior to spinal cord implantation into the lumbar (L-3-L-4) spinal cord. Rats were given daily injections of either FK506 (5 mg/kg, subcutaneous) or vehicle for 21 days. The PN grafts from FK506-treated rats contained larger sized regenerating axons compared with vehicle-treated controls, and mean axonal areas increased by 25% at 7.5 mm along the PN graft. Fluoro-Gold retrograde labeling confirmed that the regenerating axons originated from the central nervous system. Unexpectedly, the majority (>50%) of neurons in the red nucleus were retrogradely labeled in the FK506-treated animals only. The results indicate that FK506 not only accelerates the elongation of spinal cord axons but also promotes regeneration of rubrospinal neurons.
- Subjects :
- Male
Red nucleus
Central nervous system
Tacrolimus
Rats, Sprague-Dawley
Lumbar
Peripheral nerve
Neural Pathways
medicine
Animals
Peripheral Nerves
Spinal Cord Injuries
Red Nucleus
Neurons
Spinal cord implantation
business.industry
Regeneration (biology)
Anatomy
Spinal cord
Axons
Nerve Regeneration
Rats
Microscopy, Electron
medicine.anatomical_structure
nervous system
Spinal Cord
Nerve Degeneration
Regenerating axons
Neurology (clinical)
business
Immunosuppressive Agents
Subjects
Details
- ISSN :
- 10790268
- Volume :
- 22
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The journal of spinal cord medicine
- Accession number :
- edsair.doi.dedup.....70b7b4044428276d4324f68a02abe730