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Blood group antigen A type 3 expression is a favorable prognostic factor in advanced NSCLC
- Source :
- Lung cancer (Amsterdam, Netherlands). 92
- Publication Year :
- 2015
-
Abstract
- Objectives Several blood group-related carbohydrate antigens are prognosis-relevant markers of tumor tissues. A type 3 (repetitive A) is a blood group antigen specific for A 1 erythrocytes. Its potential expression in tumor tissues has so far not been examined. Material and methods We have evaluated its expression in normal lung and in lung cancer using a novel antibody (A69-A/E8). For comparison an anti-A antibody specific to A types 1 and 2 was used, because its expression on lung cancer tissue has been previously reported to be of prognostic relevance. Resected tissue samples of 398 NSCLC patients were analyzed in immunohistochemistry using tissue microarrays. Results and conclusions Expression of A type 3 was not observed in non-malignant lung tissues. A type 3 was expressed on tumor cells of around half of NSCLC patients of blood group A 1 ( p p =0.562), the expression of A type 3 by tumor cells indicated a highly significant favorable prognosis among advanced NSCLC patients ( p =0.011) and in NSCLC patients with lymphatic spread ( p =0.014). Univariate prognostic results were confirmed in a Cox proportional hazards model. In this study we present for the first time prognostic data for A type 3 antigen expression in lung cancer patients. Prospective studies should be performed to confirm the prognostic value of A type 3 expression for an improved risk stratification in NSCLC patients.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Oncology
Male
Cancer Research
medicine.medical_specialty
Pathology
Lung Neoplasms
03 medical and health sciences
0302 clinical medicine
Antigen
Antigens, Neoplasm
Internal medicine
Carcinoma, Non-Small-Cell Lung
medicine
Biomarkers, Tumor
Humans
Lung cancer
Prospective cohort study
Aged
Tissue microarray
Lung
biology
Proportional hazards model
business.industry
medicine.disease
Prognosis
Immunohistochemistry
Survival Analysis
respiratory tract diseases
030104 developmental biology
medicine.anatomical_structure
Tissue Array Analysis
030220 oncology & carcinogenesis
biology.protein
Blood Group Antigens
Female
Antibody
business
Subjects
Details
- ISSN :
- 18728332
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Lung cancer (Amsterdam, Netherlands)
- Accession number :
- edsair.doi.dedup.....70b2bbb61991987a85802a5e1cf265e7