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Vitamin D Deficiency as a Risk Factor for Myocardial Ischemia
- Source :
- Medicina, Vol 57, Iss 774, p 774 (2021), Medicina, Volume 57, Issue 8
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Background and Objectives: Vitamin D (Vit D) deficiency has been implicated in various conditions, including cardiovascular disease. The purpose of this retrospective study was to investigate the incidence of patients with myocardial ischemia in relation to their serum levels of vitamin D. Materials and Methods: A 64-month search (January 2016 to April 2021) in our database of the Nuclear Medicine Laboratory revealed 113 patients who had both myocardial perfusion imaging with single photon emission computed tomography (MPI SPECT) and Vit D measurements. MPI SPECT obtained myocardial images during both stress (summed stress score, SSS) and rest (summed rest score, SRS). Abnormal MPI SPECT was when the SSS was ≥4. Vit D was determined by radioimmunoassay (RIA). Patients with Vit D values &lt<br />10 ng/mL, 10–29 ng/mL and ≥30 ng/mL were defined as having a deficiency, insufficiency and sufficiency, respectively. Results: Among patients, 46/113 (40.7%) were male and 67/113 (59.3%) were female. Abnormal MPI was found in 58/113 (51.3%) patients. Vit D deficiency was noted in 20/113 (17.7%) patients, insufficiency in 86/113 (76.1%) patients, and normal Vit D was noted in only 7/113 (6.2%) patients. Sixteen of the 20 patients (80%) with Vit D deficiency, and 38/86 (44.2%) with insufficiency had an abnormal MPI SPECT. In contrast, only 1/7 (14.3%) patients with sufficient Vit D levels had an abnormal MPI SPECT. The Mann-Whitney U-test showed that ischemia reduced the values of Vit D. Correlation analysis showed a negative association of Vit D levels with SSS (rho = −0.232, p = 0.014) and SRS (rho = −0.250, p = 0.008). Further evaluation with a Vit D cut off 20 ng/mL retrieved no statistical significance. Finally, Vit D and gender were independently associated with myocardial ischemia. Conclusions: Low Vit D levels may represent a risk factor for myocardial ischemia.
- Subjects :
- Male
Vitamin
medicine.medical_specialty
Medicine (General)
Ischemia
030209 endocrinology & metabolism
vitamin D
Coronary Artery Disease
030204 cardiovascular system & hematology
Gastroenterology
Article
vitamin D deficiency
03 medical and health sciences
Myocardial perfusion imaging
chemistry.chemical_compound
0302 clinical medicine
R5-920
Risk Factors
Statistical significance
Internal medicine
medicine
Vitamin D and neurology
Humans
Risk factor
Retrospective Studies
medicine.diagnostic_test
business.industry
General Medicine
myocardial perfusion imaging
Vitamin D Deficiency
medicine.disease
SSS
myocardial ischemia
chemistry
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 16489144
- Volume :
- 57
- Issue :
- 774
- Database :
- OpenAIRE
- Journal :
- Medicina
- Accession number :
- edsair.doi.dedup.....70aee99fe934d73f0f2c67075adee30b