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Obstructive Sleep Apnea, Glucose Tolerance, and β-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study
- Source :
- Diabetes Care
- Publication Year :
- 2021
- Publisher :
- American Diabetes Association, 2021.
-
Abstract
- OBJECTIVE Obstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA adversely impacts pancreatic islet β-cell function remains unclear. We aimed to investigate the association of OSA and short sleep duration with β-cell function in overweight/obese adults with prediabetes or recently diagnosed, treatment-naive type 2 diabetes. RESEARCH DESIGN AND METHODS Two hundred twenty-one adults (57.5% men, age 54.5 ± 8.7 years, BMI 35.1 ± 5.5 kg/m2) completed 1 week of wrist actigraphy and 1 night of polysomnography before undergoing a 3-h oral glucose tolerance test (OGTT) and a two-step hyperglycemic clamp. Associations of measures of OSA and actigraphy-derived sleep duration with HbA1c, OGTT-derived outcomes, and clamp-derived outcomes were evaluated with adjusted regression models. RESULTS Mean ± SD objective sleep duration by actigraphy was 6.6 ± 1.0 h/night. OSA, defined as an apnea-hypopnea index (AHI) of five or more events per hour, was present in 89% of the participants (20% mild, 28% moderate, 41% severe). Higher AHI was associated with higher HbA1c (P = 0.007). However, OSA severity, measured either by AHI as a continuous variable or by categories of OSA severity, and sleep duration (continuous or CONCLUSIONS In this baseline cross-sectional analysis of the RISE clinical trial of adults with prediabetes or recently diagnosed, untreated type 2 diabetes, the prevalence of OSA was high. Although some measures of OSA severity were associated with HbA1c, OSA severity and sleep duration were not associated with measures of insulin sensitivity or β-cell responses.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Type 2 diabetes
Polysomnography
Overweight
Prediabetic State
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Diabetes mellitus
Internal medicine
Insulin Secretion
Internal Medicine
medicine
Humans
030212 general & internal medicine
Prediabetes
Pathophysiology/Complications
Advanced and Specialized Nursing
Sleep Apnea, Obstructive
medicine.diagnostic_test
business.industry
Actigraphy
Middle Aged
medicine.disease
respiratory tract diseases
Obstructive sleep apnea
Cross-Sectional Studies
Glucose
Diabetes Mellitus, Type 2
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 19355548 and 01495992
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....70abe416e1fd823d80873b87ba67c947