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Therapeutic targeting of angiogenesis molecular pathways in angiogenesis-dependent diseases
- Source :
- Biomedicine & Pharmacotherapy, Vol 110, Iss, Pp 775-785 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Angiogenesis is a critical step in the progression of almost all human malignancies and some other life-threatening diseases. Anti-angiogenic therapy is a novel and effective approach for treatment of angiogenesis-dependent diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. In this article, we will review the main strategies developed for anti-angiogenic therapies beside their clinical applications, the major challenges, and the latest advances in the development of anti-angiogenesis-based targeted therapies.
- Subjects :
- Vascular Endothelial Growth Factor A
0301 basic medicine
Angiogenesis
Angiogenesis Inhibitors
RM1-950
Therapeutic targeting
03 medical and health sciences
Drug Delivery Systems
0302 clinical medicine
Anti-angiogenesis
medicine
Angiogenesis-dependent diseases
Animals
Humans
VEGF–VEGFR system receptors
Cancer
Pharmacology
Neovascularization, Pathologic
business.industry
General Medicine
Diabetic retinopathy
Macular degeneration
medicine.disease
030104 developmental biology
Anti angiogenesis
030220 oncology & carcinogenesis
Cancer research
Cytokines
Angiogenesis Inducing Agents
Therapeutics. Pharmacology
Anti-angiogenic therapeutics
business
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 07533322
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Biomedicine & Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....70aa8ac492ffa6ecbca26822175f8394