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Multimodal characterization of compositional, structural and functional features of human atherosclerotic plaques
- Source :
- Biomedical Optics Express, Biomedical optics express, vol 2, iss 8
- Publication Year :
- 2011
- Publisher :
- Optical Society of America, 2011.
-
Abstract
- Detection of atherosclerotic plaque vulnerability has critical clinical implications for avoiding sudden death in patients with high risk of plaque rupture. We report on multimodality imaging of ex-vivo human carotid plaque samples using a system that integrates fluorescence lifetime imaging (FLIM), ultrasonic backscatter microscopy (UBM), and photoacoustic imaging (PAI). Biochemical composition is differentiated with a high temporal resolution and sensitivity at the surface of the plaque by the FLIM subsystem. 3D microanatomy of the whole plaque is reconstructed by the UBM. Functional imaging associated with optical absorption contrast is evaluated from the PAI component. Simultaneous recordings of the optical, ultrasonic, and photoacoustic data present a wealth of complementary information concerning the plaque composition, structure, and function that are related to plaque vulnerability. This approach is expected to improve our ability to study atherosclerotic plaques. The multimodal system presented here can be translated into a catheter based intraluminal system for future clinical studies.
- Subjects :
- tissue diagnostics
Aging
Fluorescence-lifetime imaging microscopy
Pathology
medicine.medical_specialty
(170.6510) Spectroscopy
Functional features
ocis:(170.6935) Tissue characterization
Photoacoustic imaging in biomedicine
Optical Physics
030204 cardiovascular system & hematology
Cardiovascular
time-resolved
(170.5120) Photoacoustic imaging
01 natural sciences
Sudden death
Multimodal Imaging
Absorption contrast
010309 optics
03 medical and health sciences
0302 clinical medicine
(110.7170) Ultrasound
ocis:(170.6510) Spectroscopy, tissue diagnostics
0103 physical sciences
Microscopy
ocis:(110.7170) Ultrasound
Medicine
ocis:(300.6500) Spectroscopy, time-resolved
screening and diagnosis
business.industry
Ultrasound
(170.6935) Tissue characterization
Materials Engineering
Atherosclerosis
Atomic and Molecular Physics, and Optics
3. Good health
Functional imaging
Detection
ocis:(170.5120) Photoacoustic imaging
(300.6500) Spectroscopy
Biomedical Imaging
business
4.2 Evaluation of markers and technologies
Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 21567085
- Volume :
- 2
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Biomedical Optics Express
- Accession number :
- edsair.doi.dedup.....70a6f1c23ae07faab8528eaf81b6589a