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Is Tumour Angiogenesis a Prognostic Factor in Patients with Colorectal Cancer and No Involved Nodes?
- Source :
- Scopus-Elsevier
- Publication Year :
- 2000
- Publisher :
- Oxford University Press (OUP), 2000.
-
Abstract
- To examine a possible association between tumour angiogenesis and conventional prognostic variables and to assess the prognostic value of the variables examined in patients with colorectal cancer, with no involved nodes.Retrospective study.University hospital, Italy.119 patients who had had colorectal cancers resected for cure with no involved nodes between 1985-1990.The three microscopic fields with the most microvessels were identified by immunohistochemical techniques. 10 high-power fields in each area were used for the microvessel count and the mean values indicated the microvessel density.Correlation of microvessel density with conventional prognostic factors, recurrence rates, and survival.There was a significant correlation between microvessel density and sex, women having a higher density than men (p0.05), but no significant correlations between density and recurrence rates or survival. Multivariate analysis did not indicate that microvessel density had a prognostic role.Microvessel density in colorectal cancer without involved nodes does not correlate with conventional prognostic factors and provides no prognostic information.
- Subjects :
- Male
Prognostic variable
medicine.medical_specialty
Multivariate analysis
Colorectal cancer
Angiogenesis
Recurrence
Carcinoma
Humans
Medicine
Microvessel
Survival analysis
Aged
Neoplasm Staging
Retrospective Studies
Analysis of Variance
Neovascularization, Pathologic
business.industry
Microcirculation
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
Survival Analysis
Surgery
Female
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 11024151
- Volume :
- 166
- Database :
- OpenAIRE
- Journal :
- The European Journal of Surgery
- Accession number :
- edsair.doi.dedup.....709b539659328782b87df7f5f77c646f