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Molecular characterization of rabies virus isolated from non-haematophagous bats in Brazil

Authors :
Silvana Regina Favoretto
Angélica Cristine de Almeida Campos
Miriam Martos Sodré
Danielle Bastos Araujo
Camila Seabra Rodrigues
Edison Luiz Durigon
Avelino Albas
Source :
Revista da Sociedade Brasileira de Medicina Tropical, Vol 44, Iss 6, Pp 678-683 (2011), Revista da Sociedade Brasileira de Medicina Tropical v.44 n.6 2011, Revista da Sociedade Brasileira de Medicina Tropical, Sociedade Brasileira de Medicina Tropical (SBMT), instacron:SBMT, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
Publication Year :
2011
Publisher :
Sociedade Brasileira de Medicina Tropical (SBMT), 2011.

Abstract

INTRODUCTION: Rabies is an important zoonosis that causes thousands of deaths worldwide each year. Although the terrestrial cycle, mainly transmitted by dogs, is controlled in Brazil, the aerial cycle remains a serious public health issue, besides the economic problem. In the aerial cycle, the haematophagous bat Desmodus rotundus is the main source of infection, where several different species of non-haematophagous bats can be infected and can transmit the virus. METHODS: The aim of this work was to study the epidemiological pattern of rabies using antigenic characterization with monoclonal antibodies and genetic characterization by reverse-transcriptase polymerase chain reaction followed by sequencing and phylogenetic analysis of non-haematophagous bats' and herbivorous animals' central nervous system samples from the western region of the State of São Paulo, Brazil. RESULTS: From 27 samples, 3 antigenic variants were identified: AgV-3, AgV-4, and AgV-6; and from 29 samples, 5 different clusters were identified, all belonging to the rabies virus species. CONCLUSIONS: Although only non-haematophagous bats were evaluated in the studied region, the majority of samples were from antigenic and genetic variants related to haematophagous bats Desmodus rotundus. Samples from the same antigenic variant were segregated in more than one genetic cluster. This study demonstrated the diversity of rabies virus genetic lineages presented and circulating in non-haematophagous bats in the studied region.

Details

Language :
English
ISSN :
16789849
Volume :
44
Issue :
6
Database :
OpenAIRE
Journal :
Revista da Sociedade Brasileira de Medicina Tropical
Accession number :
edsair.doi.dedup.....7093bd87bd9de1c22d6f4eb97e4dcaa8