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Molecular characterization of rabies virus isolated from non-haematophagous bats in Brazil
- Source :
- Revista da Sociedade Brasileira de Medicina Tropical, Vol 44, Iss 6, Pp 678-683 (2011), Revista da Sociedade Brasileira de Medicina Tropical v.44 n.6 2011, Revista da Sociedade Brasileira de Medicina Tropical, Sociedade Brasileira de Medicina Tropical (SBMT), instacron:SBMT, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2011
- Publisher :
- Sociedade Brasileira de Medicina Tropical (SBMT), 2011.
-
Abstract
- INTRODUCTION: Rabies is an important zoonosis that causes thousands of deaths worldwide each year. Although the terrestrial cycle, mainly transmitted by dogs, is controlled in Brazil, the aerial cycle remains a serious public health issue, besides the economic problem. In the aerial cycle, the haematophagous bat Desmodus rotundus is the main source of infection, where several different species of non-haematophagous bats can be infected and can transmit the virus. METHODS: The aim of this work was to study the epidemiological pattern of rabies using antigenic characterization with monoclonal antibodies and genetic characterization by reverse-transcriptase polymerase chain reaction followed by sequencing and phylogenetic analysis of non-haematophagous bats' and herbivorous animals' central nervous system samples from the western region of the State of São Paulo, Brazil. RESULTS: From 27 samples, 3 antigenic variants were identified: AgV-3, AgV-4, and AgV-6; and from 29 samples, 5 different clusters were identified, all belonging to the rabies virus species. CONCLUSIONS: Although only non-haematophagous bats were evaluated in the studied region, the majority of samples were from antigenic and genetic variants related to haematophagous bats Desmodus rotundus. Samples from the same antigenic variant were segregated in more than one genetic cluster. This study demonstrated the diversity of rabies virus genetic lineages presented and circulating in non-haematophagous bats in the studied region.
- Subjects :
- Microbiology (medical)
lcsh:Arctic medicine. Tropical medicine
Antigenic characterization
PARASITOLOGIA
Rabies
lcsh:RC955-962
Antibodies, Viral
medicine.disease_cause
Virus
law.invention
law
Phylogenetics
Chiroptera
Bats
medicine
Animals
Phylogeny
Polymerase chain reaction
biology
Phylogenetic tree
Raiva
Reverse Transcriptase Polymerase Chain Reaction
Zoonosis
Rabies virus
Caracterização genética
Antibodies, Monoclonal
Morcegos
medicine.disease
biology.organism_classification
Virology
Infectious Diseases
Caracterização antigênica
Desmodus rotundus
Cattle
Parasitology
Genetic characterization
Brazil
Subjects
Details
- Language :
- English
- ISSN :
- 16789849
- Volume :
- 44
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Revista da Sociedade Brasileira de Medicina Tropical
- Accession number :
- edsair.doi.dedup.....7093bd87bd9de1c22d6f4eb97e4dcaa8