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Frequency and predictors of confirmed hypoglycaemia in type 1 and insulin-treated type 2 diabetes mellitus patients in a real-life setting: Results from the DIALOG study
- Source :
- Diabetes & Metabolism. 41:116-125
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Aim DIALOG assessed the prevalence and predictors of hypoglycaemia in patients with type 1 (T1DM) or insulin-treated type 2 diabetes mellitus (T2DM) in a real-life setting. Methods In this observational study, insulin-treated patients ( n =3048) completed prospective daily questionnaires reporting the frequency and consequences of severe/confirmed non-severe hypoglycaemia over 30 days. Patients ( n =3743) also retrospectively reported severe hypoglycaemia over the preceding year. Results In this prospective survey, 85.3% and 43.6% of patients with T1DM and T2DM, respectively, reported experiencing at least one confirmed hypoglycaemic event over 30 days, while 13.4% and 6.4%, respectively, reported at least one severe event. Hypoglycaemia frequency increased with longer duration of diabetes and insulin therapy. Strongly predictive factors for hypoglycaemia were previous hypoglycaemia, >2 injections/day, BMI 2 and duration of insulin therapy>10 years. HbA 1c level was not predictive of hypoglycaemia in either T1DM or T2DM. The confirmed hypoglycaemia rate was increased in the lowest compared with the highest tertile of HbA 1c in T1DM, but not T2DM. At the time of enrolment, physicians reported severe hypoglycaemia in 23.6% and 11.9% of T1DM and T2DM patients, respectively, during the preceding year; the retrospective survey yielded frequencies of 31.5% and 21.7%, respectively. Also, severe hypoglycaemia led to medical complications in 10.7% and 7.8% of events in T1DM and T2DM patients, respectively, over 30 days. Conclusion Using a unique combined prospective and retrospective approach, the DIALOG study found a relatively high frequency of hypoglycaemia among insulin-treated patients. These findings emphasize the importance of a patient-centred approach for managing diabetes in which hypoglycaemia risk evaluation is critical. Trial registration ClinicalTrials.gov: NCT01628341.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pediatrics
endocrine system diseases
Endocrinology, Diabetes and Metabolism
United Kingdom Prospective Diabetes Study
medicine.medical_treatment
Type 2 diabetes
Endocrinology
Risk Factors
Diabetes mellitus
Prevalence
Internal Medicine
medicine
Humans
Hypoglycemic Agents
Insulin
Prospective Studies
Case report form
Aged
Retrospective Studies
Type 1 diabetes
business.industry
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
General Medicine
Middle Aged
medicine.disease
Hypoglycemia
Surgery
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Female
business
Body mass index
Subjects
Details
- ISSN :
- 12623636
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Diabetes & Metabolism
- Accession number :
- edsair.doi.dedup.....707963daac66e8c01dbd757d0290baaf