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Long term metabolic impact of high protein neonatal feeding: a preliminary study in male rat pups born with a low birth weight
- Source :
- Clinical nutrition (Edinburgh, Scotland). 31(5)
- Publication Year :
- 2012
-
Abstract
- Nutrition received in early life may impact adult health. The aim of the study was to determine whether high protein feeding in neonatal period would have long term metabolic effects in an animal model of low birth weight infants.Male rat pups born from dams receiving a low protein diet during gestation were separated from their mothers, and equipped with gastrostomy tubes to receive as their sole feeding a milk formula of either adequate protein (AP; n = 14; 8.7 g protein/dL; total energy: 155 kcal/100 g), or high protein content (HP; n = 14; 13.0 g protein/dL; total energy: 171 kcal/100 g) between the 7th (D7) and 21st day (D21) of life. Rats were then weaned to standard chow until sacrificed at adulthood.At D18, HP feeding was associated with higher estimated rates of protein turnover (p = 0.007) and synthesis (p = 0.051), as assessed using l-[U-(13)C]valine infusion. HP milk feeding in early life was associated with an increase in weight gain from puberty through adulthood, along with an increase in food intake, serum insulin (179 ± 58 vs. 55 ± 7 pmol/L; means ± SE), pancreatic β-cell number, plasma triglycerides (95 ± 8 vs. 73 ± 9 mg/dL), serum leptin (9.7 ± 1.0 vs. 5.5 ± 1.2 ng/mL), mesenteric fat mass, and adipocyte size.In an animal model of low birth weight infants, high protein neonatal feeding may have a lasting effect on fat and glucose metabolism, potentially leading to "metabolic syndrome" in adulthood.
- Subjects :
- Blood Glucose
Leptin
Male
medicine.medical_specialty
030309 nutrition & dietetics
G protein
medicine.medical_treatment
Intrauterine growth restriction
Critical Care and Intensive Care Medicine
Rats, Sprague-Dawley
03 medical and health sciences
Low-protein diet
Valine
Internal medicine
Medicine
Animals
Pancreas
030304 developmental biology
2. Zero hunger
0303 health sciences
Nutrition and Dietetics
business.industry
Body Weight
Protein turnover
medicine.disease
Lipid Metabolism
Hormones
Diet
Rats
Low birth weight
Endocrinology
Adipose Tissue
Animals, Newborn
Gestation
Female
Dietary Proteins
medicine.symptom
business
Energy Intake
Weight gain
Subjects
Details
- ISSN :
- 15321983
- Volume :
- 31
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinical nutrition (Edinburgh, Scotland)
- Accession number :
- edsair.doi.dedup.....706db067cda8816be9e9821b43e81b49