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Different factors influence recanalisation rate after coiling in ruptured and unruptured intracranial aneurysms
- Source :
- CNSneurological disorders drug targets. 12(2)
- Publication Year :
- 2012
-
Abstract
- Background: Most studies evaluating long-term efficacy after coil embolisation of intracranial aneurysms have not differentiated between ruptured and unruptured aneurysms. Objectives: The aim of this study was to analyse factors that influence recanalisation in ruptured and unruptured aneurysms. Methods: We performed a retrospective analysis of 182 (98 ruptured, 84 unruptured) aneurysms, treated with coil embolisation alone that received follow-up with digital substraction angiography (DSA). Results: At 6 months 26% of the aneurysms showed recanalisation. Multivariate variance analysis revealed that different factors influenced recanalisation in ruptured and unruptured aneurysms. In ruptured aneurysms patient age was a determinant, with younger patients recanalising more frequently than older ones (p = 0.016). Also, low initial packing density led to higher recanalisation rates (p = 0.015) than higher packing. In the unruptured aneurysm group these factors were not significant. Here, only a larger aneurysm volume led to higher recanalisation rates (p = 0.027). Conclusions: Our data suggest that in ruptured aneurysms, high packing density is a key factor to prevent recanalisation, while in unruptured aneurysms, aneurysm volume is the main predictor for recanalisation.
- Subjects :
- Male
medicine.medical_specialty
Ruptured aneurysms
Aneurysm, Ruptured
Statistics, Nonparametric
Aneurysm
Patient age
Retrospective analysis
Medicine
Humans
cardiovascular diseases
Longitudinal Studies
A determinant
Coil embolization
Retrospective Studies
Pharmacology
medicine.diagnostic_test
business.industry
General Neuroscience
Angiography, Digital Subtraction
Intracranial Aneurysm
Middle Aged
medicine.disease
Surgical Instruments
Embolization, Therapeutic
Surgery
Treatment Outcome
Angiography
cardiovascular system
Unruptured aneurysm
Female
Radiology
business
Subjects
Details
- ISSN :
- 19963181
- Volume :
- 12
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- CNSneurological disorders drug targets
- Accession number :
- edsair.doi.dedup.....7068b8d42fbd38c36f0293f410b4e99a