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Differentiating of cross-reactions in patients with latex allergy with the use of ISAC test
- Source :
- Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, Advances in Dermatology and Allergology, Vol 33, Iss 2, Pp 120-127 (2016)
- Publication Year :
- 2014
-
Abstract
- Introduction : Differentiating between cross-reactivity and double sensitization is still a challenging issue in allergology. Aim : To differentiate cross-reactions accompanying latex allergy with the use of the ISAC test. Material and methods : Thirty-nine patients reporting immediate allergic reactions to latex were enrolled into the study (group A). The control group was comprised of 41 patients with allergic diseases not associated with latex (group B) and 20 healthy individuals (group C). Their history was recorded and skin prick tests were performed with latex, airborne and food allergens. Specific IgE against food allergens, latex (k82) and recombined latex allergens were determined. Immun o CAP ISAC test was performed with 103 molecules. Results : Sensitization to latex was found by means of skin tests in 16 cases and sIgE against latex was revealed in 12 cases (including 10 positive in both SPT and sIgE). In the ISAC test antibodies against recombined latex allergens were found in 8 patients with rHev β 6 as the most common. All the patients positive for rHev β 1, 5, 6, 8 had allergy or asymptomatic sensitization to food allergens cross-reacting with latex. Some reactions could not have been differentiated due to the lack of allergens in the ISAC test. Others, not related to latex-fruits syndrome were explained by cross-reactivity with other profilins or PR-10 proteins. Conclusions : Immun o CAP ISAC test could be useful in differentiating between cross-reactions and double sensitizations. However, in the case of latex its advantages are limited due to a small panel of allergens.
- Subjects :
- 0301 basic medicine
lcsh:Internal medicine
Allergy
cross-reactivity
ISAC test
Dermatology
Immunoglobulin E
medicine.disease_cause
Cross-reactivity
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
lcsh:Dermatology
medicine
Immunology and Allergy
In patient
Food allergens
latex allergy
lcsh:RC31-1245
Sensitization
Original Paper
biology
business.industry
Cross reactions
lcsh:RL1-803
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Latex allergy
Immunology
biology.protein
business
Subjects
Details
- ISSN :
- 1642395X
- Volume :
- 33
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Postepy dermatologii i alergologii
- Accession number :
- edsair.doi.dedup.....706433fb678b4435cb7c1031e0838a15