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Targeting the Epigenome for the Treatment and Prevention of Lung Cancer
- Source :
- Seminars in Oncology. 32:488-502
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Alterations in chromatin structure resulting from aberrant DNA methylation and perturbations of the histone code profoundly influence gene expression during pulmonary carcinogenesis. Recent studies indicate that DNA demethylating agents and histone deacetylase (HDAC) inhibitors synergistically induce gene expression and apoptosis in cultured lung cancer cells, and prevent lung cancer development in animals following exposure to tobacco carcinogens. Preliminary clinical trials have established proof of principle regarding the use of DNA demethylating agents and HDAC inhibitors for enhancing immunogenicity and apoptosis of lung cancer cells, and have revealed the complexities concerning the mechanisms by which chromatin remodeling agents mediate antitumor effects in vivo. These data support additional investigations pertaining to the epigenetics of lung cancer, and the evaluation of chromatin remodeling agents for the treatment and prevention of this disease.
- Subjects :
- Lung Neoplasms
Time Factors
Antineoplastic Agents
Apoptosis
medicine.disease_cause
Chromatin remodeling
Epigenesis, Genetic
Histones
Cell Line, Tumor
Animals
Humans
Histone code
Medicine
Epigenetics
Cancer epigenetics
Enzyme Inhibitors
Clinical Trials as Topic
business.industry
Hematology
Epigenome
DNA Methylation
Flow Cytometry
Chromatin
Gene Expression Regulation, Neoplastic
Histone Deacetylase Inhibitors
Oncology
DNA methylation
Cancer research
business
Carcinogenesis
Subjects
Details
- ISSN :
- 00937754
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Seminars in Oncology
- Accession number :
- edsair.doi.dedup.....70635bf06955244ab153008a88f5f67a