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A Case of Livedoid Vasculopathy Successfully Treated with Sulodexide
- Source :
- Annals of Dermatology
- Publication Year :
- 2020
- Publisher :
- The Korean Dermatological Association; The Korean Society for Investigative Dermatology, 2020.
-
Abstract
- We report a 29-year-old female with a one-month history of non-healing multiple erythematous to violaceous plaques with crusts over both legs and feet. Tender, scarring ulcers with surrounding erythema were present. The clinical manifestation, together with histopathologic findings of fibrinoid plugs within vascular lumens and walls, as well as red blood cell extravasation, led to diagnosis of livedoid vasculopathy. The patient experienced recurrent painful violaceous plaques with ulcerations during the two years of treatment with oral pentoxifylline 400 mg three times daily. The cutaneous lesions and symptoms dramatically improved after the treatment regimen changed to oral sulodexide (250 lipasemic units) three times daily. Sulodexide, a highly purified mixture of glycosaminoglycans including dermatan sulfate and low-molecular weight heparin, could be an effective therapy for recalcitrant livedoid vasculopathy. Herein, we report a case of livedoid vasculopathy treated with sulodexide, which has not previously been reported.
- Subjects :
- medicine.medical_specialty
Erythema
Case Report
Vasculopathy
Dermatology
Clinical manifestation
Dermatan sulfate
Glycosaminoglycan
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
Sulodexide
0302 clinical medicine
medicine
Heparinoids
business.industry
Anticoagulants
Livedoid
Heparin
Extravasation
chemistry
030220 oncology & carcinogenesis
medicine.symptom
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20053894 and 10139087
- Volume :
- 32
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Annals of Dermatology
- Accession number :
- edsair.doi.dedup.....70635b2e3ba6d4ab7f52abbbaa0ad4a0