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Effects of thyroid hormones on aortic tissue after myocardial infarction in rats

Authors :
Cristina Campos
Tânia R.G. Fernandes
Adriane Belló-Klein
Rafaela Siqueira
Alex Sander da Rosa Araujo
Adriana Conzatti
Jéssica Hellen Poletto Bonetto
Vanessa Duarte Ortiz
Rafael Oliveira Fernandes
Alexandre Luz de Castro
Source :
European Journal of Pharmacology. 791:788-793
Publication Year :
2016
Publisher :
Elsevier BV, 2016.

Abstract

Studies have shown a cardioprotective role of thyroid hormones (THs) in cardiac remodeling after acute myocardial infarction (MI). However, there is no data in the literature examining the influence of TH administration on the aortic tissue in an animal model of MI. This study aimed to evaluate the effects of thyroid hormones on the aorta after MI. Male Wistar rats were divided into a sham group (SHAM), infarcted group (AMI), sham+TH (SHAMT) and AMI+TH (AMIT). After MI, the animals received T3 and T4 (2 and 8 μg/100 g/day, respectively) by oral gavage for 12 days. Later, the animals underwent echocardiography and euthanasia and the aorta was collected for molecular and biochemical analysis. T3 and T4 administration increased the expression of the pro-angiogenic proteins vascular endothelial growth factor (VEGF) and hypoxia inducible factor 1α (HIF-1α) in the aorta of AMIT rats when compared with AMI. With respect to TH receptors, AMI rats presented a decrease in TRβ levels, which was prevented by the hormonal administration. In AMIT rats, both TRα and TRβ levels were increased when compared with the AMI group. Reactive oxygen species levels and NADPH oxidase activity were decreased in both treated groups when compared with the non-treated animals. TH administration after MI may improve angiogenic signaling in the aorta as well as the responsiveness of this vessel to T3 and T4. These positive effects in the aorta may result in additional protection for the cardiovascular system in the context of cardiac ischaemic injury.

Details

ISSN :
00142999
Volume :
791
Database :
OpenAIRE
Journal :
European Journal of Pharmacology
Accession number :
edsair.doi.dedup.....705d4f604ec3f9932b0cb2d38c6b3c22
Full Text :
https://doi.org/10.1016/j.ejphar.2016.10.022