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Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization
- Source :
- WORLD JOURNAL OF GASTROENTEROLOGY
- Publication Year :
- 2014
- Publisher :
- Baishideng Publishing Group Inc., 2014.
-
Abstract
- Hepatitis C virus (HCV) infections represent a major global health problem. End-stage liver disease caused by chronic HCV infection is a major indication for liver transplantation. However, after transplantation the engrafted liver inevitably becomes infected by the circulating virus. Direct acting antivirals are not yet approved for use in liver transplant patients, and limited efficacy and severe side effects hamper the use of pegylated interferon combined with ribavirin in a post-transplant setting. Therefore, alternative therapeutic options need to be explored. Viral entry represents an attractive target for such therapeutic intervention. Understanding the mechanisms of viral entry is essential to define the viral and cellular factors involved. The HCV life cycle is dependent of and associated with lipoprotein physiology and the presence of lipoproteins has been correlated with altered antiviral efficacy of entry inhibitors. In this review, we summarise the current knowledge on how lipoprotein physiology influences the HCV life cycle. We focus especially on the influence of lipoproteins on antibodies that target HCV envelope proteins or antibodies that target the cellular receptors of the virus. This information can be particularly relevant for the prevention of HCV re-infection after liver transplantation.
- Subjects :
- medicine.medical_treatment
Hepacivirus
Antiviral therapy
Liver transplantation
medicine.disease_cause
Hepatitis
chemistry.chemical_compound
Liver disease
Medicine and Health Sciences
Topic Highlight
Virulence
SCAVENGER RECEPTOR-BI
Gastroenterology
SURFACE HEPARAN-SULFATE
General Medicine
PRIMARY HUMAN HEPATOCYTES
LIVER-TRANSPLANTATION
Lipids
Animal models
HYPERVARIABLE REGION 1
Treatment Outcome
Liver
Host-Pathogen Interactions
Lipoproteins
Hepatitis C virus
LOW-DENSITY-LIPOPROTEIN
Biology
Antiviral Agents
Virus
Neutralisation
Viral entry
medicine
Animals
Humans
SERUM AMYLOID-A
Ribavirin
Hepatitis C Antibodies
Hepatitis C, Chronic
Virus Internalization
medicine.disease
Antibodies, Neutralizing
Virology
Liver Transplantation
Transplantation
TO-CELL TRANSMISSION
chemistry
B TYPE-I
Immunology
Virus Activation
VIRION-ASSOCIATED CHOLESTEROL
Subjects
Details
- ISSN :
- 10079327
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....705b70f36417f263e866ebdc2a1b7359