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A interação entre aromatase, metalloproteinase 2, 9 e cd44 no câncer de mama
- Source :
- Revista da Associação Médica Brasileira v.56 n.4 2010, Revista da Associação Médica Brasileira, Associação Médica Brasileira (AMB), instacron:AMB, Revista da Associação Médica Brasileira, Volume: 56, Issue: 4, Pages: 472-477, Published: 2010
- Publication Year :
- 2010
-
Abstract
- OBJECTIVE: This study intends to verify the expression levels and correlation of aromatase, matrix metalloproteinase 2 (MMP-2), matrix metalloproteinase 9 (MMP-9) and CD44 in ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma (IDC) when both are found in the same breast. METHODS: One hundred and ten cases were evaluated by tissue microarray (TMA) and immunohistochemically screened with anti-aromatase polyclonal antibodies, anti-MMP-2 monoclonal antibodies, anti-MMP-9 policlonal antibodies and anti-CD44 monoclonal antibodies. RESULTS: Aromatase was expressed in IDC and DCIS in 63 (57.3%) and 60 (67%) of the cases respectively; MMP-2 was similarly expressed in IDC and DCIS in 15 (13.60%) cases; MMP-9 was positively expressed in IDC and DCIS in 83 (75.50%) and 82 (74.50%) cases, respectively; CD44 was positively expressed in IDC and DCIS in 49 (44.50%) and 48 (42.60%) of the cases, respectively; all of them were highly correlated (p
- Subjects :
- Pathology
medicine.medical_specialty
medicine.drug_class
Matrix metalloproteinase 9
Metaloproteinase 9 da matriz
Breast Neoplasms
Monoclonal antibody
Matrix metalloproteinase 2
Breast cancer
Aromatase
Antigens CD44
medicine
Humans
skin and connective tissue diseases
neoplasms
Metalloproteinase
Tissue microarray
biology
business.industry
CD44
Carcinoma, Ductal, Breast
General Medicine
Carcinoma ductal breast
Ductal carcinoma
medicine.disease
Immunohistochemistry
Neoplasm Proteins
body regions
Hyaluronan Receptors
Matrix Metalloproteinase 9
Polyclonal antibodies
Antígenos CD44
biology.protein
Cancer research
Carcinoma ductal de mama
Matrix Metalloproteinase 2
Female
business
Metaloproteinase 2 da matriz
Carcinoma in Situ
Subjects
Details
- ISSN :
- 18069282
- Volume :
- 56
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Revista da Associacao Medica Brasileira (1992)
- Accession number :
- edsair.doi.dedup.....704dc37bec067519bbccedde53d0350a