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Efficacy of multimodal exercise-based rehabilitation on physical activity, cardiorespiratory fitness, and patient-reported outcomes in cancer survivors: a randomized, controlled trial
- Source :
- Midtgaard, J, Christensen, J F, Tolver, A, Jones, L W, Uth, J, Rasmussen, B, Tang, L, Adamsen, L & Rørth, M 2013, ' Efficacy of multimodal exercise-based rehabilitation on physical activity, cardiorespiratory fitness, and patient-reported outcomes in cancer survivors : a randomized, controlled trial ', Annals of Oncology, vol. 24, no. 9, pp. 2267-2273 . https://doi.org/10.1093/annonc/mdt185
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Background: Sedentary behavior and impaired cardiovascular reserve capacity are common late effects of cancer therapy emphasizing the need for effective strategies to increase physical activity (PA) in cancer survivors. We examined the efficacy of a 12-month exercise-based rehabilitation program on self-reported PA, cardiorespiratory fitness (VO 2peak), strength, and patient-reported outcomes. Patients and methods: Two hundred fourteen post-treatment cancer survivors were randomly assigned to a 12-month rehabilitation program consisting of individual (x3) and group-based (x6) counseling in combination with once weekly high-intensity group-based exercise training (the Copenhagen Physical Activity after Cancer Treatment, PACT; n = 108) or to a health evaluation program (HE, n = 106). Study outcomes were assessed at baseline, 6 months, and 12 months. Results: After 12 months, the percentage of patients reporting meeting PA goal behavior (≥3 h/week) was significantly increased in the PACT group versus the HE group (70.4% versus 43.4%, P = 0.001). Repeated measures analyses indicated a statistically significant improvement in VO 2peak (l min -1) in favour of PACT (treatment effect ratio = 1.04; 95% confidence interval 1.00-1.07; P = 0.032). Significant between group differences were also observed for strength (P < 0.001), depression (P = 0.020) and mental health (P = 0.040). Conclusion: A 12-month exercise-based rehabilitation program is an effective strategy to promote PA and improve VO 2peak in cancer survivors.
- Subjects :
- Adult
Male
medicine.medical_specialty
Physical activity behavior
Cancer survivors
Health Status
medicine.medical_treatment
Physical fitness
Physical exercise
Motor Activity
law.invention
Research Support, N.I.H., Extramural
Quality of life
Randomized controlled trial
law
Neoplasms
Journal Article
medicine
Humans
Survivors
Cardiorespiratory fitness
Exercise
Aged
Rehabilitation
business.industry
Repeated measures design
Hematology
Middle Aged
Confidence interval
Treatment Outcome
Oncology
Physical Fitness
Randomized Controlled Trial
Quality of Life
Physical therapy
Female
business
Rct
Subjects
Details
- ISSN :
- 09237534
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Annals of Oncology
- Accession number :
- edsair.doi.dedup.....70463fde21ea24e17df37aff9e342844