Back to Search
Start Over
The Role of Feedback Control Design in Developing Anemia Management Protocols
- Source :
- Ann Biomed Eng
- Publication Year :
- 2019
-
Abstract
- The optimal use of erythropoiesis stimulating agents to treat anemia of end-stage renal disease remains difficult due to reported associations with adverse events. A patient's hemoglobin response to these agents cannot be accurately described using population-level models due to many individual factors including chronic inflammation, red blood cell lifespan, and acute blood loss. As a consequence, it is generally understood that current one-size-fits-all anemia management protocols result in suboptimal outcomes. In this paper, we report on our collaboration with the medical community in designing anemia management protocols. In clinical implementation, these new dosing protocols have led to improved outcomes due to their use of control-relevant modelling, model parameter identification, and principles of feedback control. This is an example of medical professionals and control engineers working together to positively affect the performance of anemia management protocols in end-stage renal disease.
- Subjects :
- medicine.medical_specialty
Anemia
Feedback control
0206 medical engineering
Biomedical Engineering
02 engineering and technology
Disease
Kidney
Models, Biological
Article
Hemoglobins
Clinical Protocols
medicine
Humans
Erythropoiesis
Dosing
Intensive care medicine
Adverse effect
Feedback, Physiological
business.industry
medicine.disease
020601 biomedical engineering
Anemia management
Model parameter
Hematinics
Kidney Failure, Chronic
business
Subjects
Details
- ISSN :
- 15739686
- Volume :
- 49
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Annals of biomedical engineering
- Accession number :
- edsair.doi.dedup.....703b1964b4a1a869cfb7e728e2e97c5f