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Drug discovery against H1N1 virus (influenza A virus) via computational virtual screening approach
- Source :
- IndraStra Global.
- Publication Year :
- 2011
- Publisher :
- BIRKHAUSER BOSTON INC, 2011.
-
Abstract
- The H1N1 virus is the causative agent of the recent outbreak of Swine flu pandemic. Neuraminidase is an enzyme that cleave glycosidic linkage of neuraminic acid on viral cell surface and is known to occur as antigen determinant to evoke immune response in host cell. It plays an important role in life cycle of influenza virus. Inhibitors of neuraminidase are, therefore, believed to have a potential in development of new drugs against swine flu. Using a recently published model structure of neuraminidase, we have carried out virtual screening of 70 compounds obtained from Ligand databases. The ligands library also included 57 natural plant metabolites from medicinal plants. The virtual screening was performed via PatchDock & GemDock softwares. Two of the plant metabolites, Hesperidin & Narirutin showed significantly higher docking score than the currently marketed anti-influenza drug Oseltamivir (Tamiflu).
- Subjects :
- Oseltamivir
Flu
H1n1 Influenza Virus
Biology
medicine.disease_cause
Narirutin
Virus
Docking
Oseltamivir (Tamiflu)
chemistry.chemical_compound
Neuraminic acid
Pandemic
Influenza A virus
medicine
General Pharmacology, Toxicology and Pharmaceutics
Virtual screening
Drug discovery
Hesperidin
Organic Chemistry
Antiviral Compound
Virology
chemistry
Swine Flu
biology.protein
Infection
Neuraminidase
Subjects
Details
- Language :
- English
- ISSN :
- 23813652
- Database :
- OpenAIRE
- Journal :
- IndraStra Global
- Accession number :
- edsair.doi.dedup.....70374bb0ec9628db36a2c613e8a8de05