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Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells
- Source :
- Molecular and cellular biology. 7(6)
- Publication Year :
- 1987
-
Abstract
- We have isolated cDNAs representing a previously unrecognized human gene that apparently encodes a protein-tyrosine kinase. We have designated the gene as HCK (hemopoietic cell kinase) because its expression is prominent in the lymphoid and myeloid lineages of hemopoiesis. Expression in granulocytic and monocytic leukemia cells increases after the cells have been induced to differentiate. The 57-kilodalton protein encoded by HCK resembles the product of the proto-oncogene c-src and is therefore likely to be a peripheral membrane protein. HCK is located on human chromosome 20 at bands q11-12, a region that is affected by interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders. Our findings add to the diversity of protein-tyrosine kinases that may serve specialized functions in hemopoietic cells, and they raise the possibility that damage to HCK may contribute to the pathogenesis of some human leukemias.
- Subjects :
- B-Lymphocytes
Leukemia
Base Sequence
Chromosomes, Human, Pair 20
Chromosome Mapping
Cell Biology
DNA
Protein-Tyrosine Kinases
Proto-Oncogene Mas
Cell Line
Chromosome Banding
Molecular Weight
Genes
Sequence Homology, Nucleic Acid
Proto-Oncogenes
Leukocytes
Humans
Amino Acid Sequence
Molecular Biology
Research Article
Subjects
Details
- ISSN :
- 02707306
- Volume :
- 7
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Molecular and cellular biology
- Accession number :
- edsair.doi.dedup.....702b14be5dd107140dd5a198f1f57591