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Association between skeletal muscle inflammatory markers and walking pattern in people with knee osteoarthritis
- Source :
- Arthritis careresearch. 63(12)
- Publication Year :
- 2011
-
Abstract
- Objective Patients with knee osteoarthritis (OA) are characterized by increased muscle inflammation and altered gait. We investigated the association between proinflammatory mediators in the vastus lateralis and physical function and gait in patients with knee OA. Methods Nineteen patients with knee OA underwent gait analysis, assessment of self-reported pain and physical function (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]), and a muscle biopsy that was taken during their knee replacement surgery. Muscle was analyzed for cellular protein inflammatory mediators, interleukin-6, monocyte chemotactic protein 1 (MCP-1), p65 NF-κB, signal transducer and activator of transcription 3 (STAT-3), and JNK-1. Sagittal plane knee function, including early stance knee range of motion (ROM) and knee sagittal plane impulse, was measured using a motion analysis system. Pearson's correlation was used to assess relationships between selected variables. Results Significant positive correlations were found between MCP-1 and self-perceived stiffness, physical function, and the total WOMAC score (P < 0.05). MCP-1 was also negatively correlated with early stance knee ROM (r = −0.52, P = 0.023). Reduced velocity was associated with elevated levels of p65 NF-κB and STAT-3 (P < 0.05). Knee sagittal plane impulse was negatively correlated with JNK-1 (P = 0.02), indicating reduction in knee impulse with an increased level of JNK-1. Conclusion Increased levels of several proinflammatory mediators were correlated with altered knee function during walking as well as greater physical disability and slower gait velocity. Identification of the cellular and molecular mechanisms associated with muscle inflammation is important to better understand the underlying mechanism responsible for altered gait and function in patients with knee OA.
- Subjects :
- musculoskeletal diseases
Male
STAT3 Transcription Factor
medicine.medical_specialty
WOMAC
Victoria
medicine.medical_treatment
Biopsy
Knee replacement
Osteoarthritis
Walking
Quadriceps Muscle
Disability Evaluation
Physical medicine and rehabilitation
Rheumatology
Medicine
Humans
Mitogen-Activated Protein Kinase 8
Range of Motion, Articular
Gait
Chemokine CCL2
Aged
Pain Measurement
Muscle biopsy
medicine.diagnostic_test
business.industry
Interleukin-6
Transcription Factor RelA
Middle Aged
Osteoarthritis, Knee
musculoskeletal system
medicine.disease
Sagittal plane
Biomechanical Phenomena
medicine.anatomical_structure
Cross-Sectional Studies
Gait analysis
Female
Self Report
Inflammation Mediators
business
Range of motion
human activities
Biomarkers
Subjects
Details
- ISSN :
- 21514658
- Volume :
- 63
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Arthritis careresearch
- Accession number :
- edsair.doi.dedup.....7029522b37a32a09d1f082ef6f0d4373