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Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
- Source :
- Advanced Science, Krüger, F, Kumar, V, Monge, P, Conzelmann, C, Smith, N, Gothelf, K V, Tolstrup, M, Münch, J & Zelikin, A N 2019, ' Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues ', Advanced Science, vol. 6, no. 6, 1802095 . https://doi.org/10.1002/advs.201802095
- Publication Year :
- 2018
-
Abstract
- Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.
- Subjects :
- Scaffold
Macromolecular prodrugs
General Chemical Engineering
General Physics and Astronomy
Medicine (miscellaneous)
02 engineering and technology
010402 general chemistry
01 natural sciences
Biochemistry, Genetics and Molecular Biology (miscellaneous)
chemistry.chemical_compound
antivirals
prodrugs
General Materials Science
Nature inspired
Communication
General Engineering
Prodrug
021001 nanoscience & nanotechnology
herpes simplex virus
Combinatorial chemistry
Communications
0104 chemical sciences
nucleic acids
Deoxyribose
chemistry
nucleoside analogues
Phosphodiester bond
Nucleic acid
0210 nano-technology
Nucleoside
Subjects
Details
- ISSN :
- 21983844
- Volume :
- 6
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Advanced science (Weinheim, Baden-Wurttemberg, Germany)
- Accession number :
- edsair.doi.dedup.....700909f5d4dd44d99969a8b45e0fa614