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Human Herpesvirus 8 Cellular Immune Responses in Homosexual Men
- Source :
- The Journal of Infectious Diseases. 180:1682-1685
- Publication Year :
- 1999
- Publisher :
- Oxford University Press (OUP), 1999.
-
Abstract
- Little is known about cellular immunity to human herpesvirus 8 (HHV-8), the virus associated with Kaposi's sarcoma (KS). T cell proliferative responses to purified HHV-8 were measured in homosexual men, a group with elevated HHV-8 seroprevalence and high risk of KS. None of 20 blood donor controls had T cell responses to HHV-8. Among human immunodeficiency virus (HIV)-negative homosexual men, 8 (42%) of 19 HHV-8 seropositive men responded as did 4 (16%) of 25 HHV-8 seronegative men. Among HIV-positive homosexual men, however, none of 21 HHV-8 seropositives had T cell responses to HHV-8, even though most responded to common recall antigens, and 10 had >/=400 CD4 cells/mm3. The results suggest that HHV-8 T cell proliferative responses are common in HIV-negative homosexual men and that HIV infection may be associated with diminished HHV-8 cellular immunity, possibly before there is substantial depletion of CD4 cells. If correct, this could explain why KS occurs relatively early in HIV infection/AIDS.
- Subjects :
- Male
Cellular immunity
T-Lymphocytes
viruses
T cell
Blood Donors
HIV Infections
Biology
Antibodies, Viral
Lymphocyte Activation
medicine.disease_cause
Virus
Herpesviridae
Immune system
Acquired immunodeficiency syndrome (AIDS)
HIV Seronegativity
Immunopathology
medicine
Humans
Immunology and Allergy
Gammaherpesvirinae
Homosexuality, Male
Antigens, Viral
virus diseases
Herpesviridae Infections
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
medicine.disease
Virology
Infectious Diseases
medicine.anatomical_structure
Herpesvirus 8, Human
Immunology
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 180
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....6ffa663a183129bbd37a25c63e99cbc5
- Full Text :
- https://doi.org/10.1086/315056