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A reduction in anti-tuberculosis drug resistance after the implementation of the national 'STOP TB' program in central Taiwan, 2003-2007
- Source :
- Japanese journal of infectious diseases. 66(2)
- Publication Year :
- 2013
-
Abstract
- The aim of this study was to determine the performance of the national "STOP TB" program in central Taiwan during 2003-2007 by examining trends in the combined drug resistance to first-line anti-tuberculosis (TB) drugs among clinical Mycobacterium tuberculosis isolates. Using 4,819 clinical M. tuberculosis isolates obtained from two mycobacteriology referral laboratories, the resistance to drugs was measured and analyzed along with the treatment outcomes in notified TB patients. The proportion of isolates showing total resistance and multidrug-resistant tuberculosis (MDR-TB) isolates were 17.7% and 3.67%, respectively. More number of MDR-TB isolates showed high-level resistance to isoniazid (84.18%) and streptomycin (SM) (30.51%); low-level resistance to ethambutol (EMB) (61.58%), SM (41.81%), and pyrazinamide (66.1%); and resistance to ofloxacin (30.4%). However, fewer isolates showed high-level resistance to EMB (19.77%), levofloxacin (17.9%), moxifloxacin (19.6%), kanamycin (8.9%), amikacin (8.9%), and capreomycin (8.9%). Of these MDR-TB isolates, 7.1% were extensively drug-resistant. Trends in combined drug resistance to all the first-line anti-TB drugs and the incidence of MDR-TB were stable during the 2 years (2003-2004) before the implementation of the national "STOP TB" program. After the "STOP TB" program, there were significant declines in the incidence of MDR-TB during 2005-2007 in central Taiwan as well as improved TB-treatment outcomes. Thus, the national "STOP TB" program had a significant positive impact on TB control in central Taiwan.
- Subjects :
- Microbiology (medical)
Male
medicine.medical_specialty
Tuberculosis
Capreomycin
Antitubercular Agents
Taiwan
Drug resistance
Mycobacterium tuberculosis
Levofloxacin
Moxifloxacin
Internal medicine
Drug Resistance, Multiple, Bacterial
Tuberculosis, Multidrug-Resistant
Medicine
Humans
Ethambutol
biology
business.industry
Health Policy
Incidence
General Medicine
Pyrazinamide
medicine.disease
biology.organism_classification
Virology
Infectious Diseases
Treatment Outcome
Communicable Disease Control
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 18842836
- Volume :
- 66
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Japanese journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....6ff88eb14d7db9937d6e971a6f927286