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The Biodistribution and Radiation Dosimetry of the Arg-Gly-Asp Peptide 18F-AH111585 in Healthy Volunteers
- Source :
- Journal of Nuclear Medicine. 49:1664-1667
- Publication Year :
- 2008
- Publisher :
- Society of Nuclear Medicine, 2008.
-
Abstract
- We report the safety, biodistribution, and internal radiation dosimetry of a new PET tracer, (18)F-AH111585, a peptide with a high affinity for the alpha(v)beta(3) integrin receptor involved in angiogenesis.PET scans of 8 healthy volunteers were acquired at time points up to 4 h after a bolus injection of (18)F-AH111585. (18)F activity in whole blood and plasma and excreted urine were measured up to 4 h after injection. In vivo (18)F activities in up to 12 source regions were determined from quantitative analysis of the images. The cumulated activities subsequently calculated were then used to determine the internal radiation dosimetry, including the effective dose.Injection of (18)F-AH111585 was well tolerated in all subjects, with no serious or drug-related adverse events reported. The main route of (18)F excretion was renal (37%), and the 3 highest initial uptakes were by liver (15%); combined walls of the small, upper large, and lower large intestines (11%); and kidneys (9%). The 3 highest absorbed doses were received by the urinary bladder wall (124 microGy/MBq), kidneys (102 microGy/MBq), and cardiac wall (59 microGy/MBq). The effective dose was 26 microGy/MBq.(18)F-AH111585 is a safe PET tracer with a dosimetry profile comparable to other common (18)F PET tracers.
- Subjects :
- Male
Biodistribution
Pyridines
Glycine
Peptide
Urine
Arginine
Radiation Dosage
Effective dose (radiation)
Excretion
In vivo
Humans
Medicine
Dosimetry
Tissue Distribution
Radiology, Nuclear Medicine and imaging
Radiometry
Aged
Whole blood
chemistry.chemical_classification
Aspartic Acid
business.industry
Middle Aged
chemistry
Positron-Emission Tomography
Azetidines
Female
Radiopharmaceuticals
Peptides
business
Nuclear medicine
Subjects
Details
- ISSN :
- 2159662X and 01615505
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Journal of Nuclear Medicine
- Accession number :
- edsair.doi.dedup.....6ff7084b66b702bb1a9c175002947912
- Full Text :
- https://doi.org/10.2967/jnumed.108.052126