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Salvianolic Acid A Suppresses DNCB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice
- Source :
- Evidence-based Complementary and Alternative Medicine : eCAM, Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
- Publication Year :
- 2021
-
Abstract
- Prevalence of atopic dermatitis (AD), a chronic, pruritic, and relapsing inflammatory skin disorder, is growing. Because available therapeutics is limited, immune regulators from natural resources could be helpful for treating AD symptoms. The root of Salvia miltiorrhiza Bunge (Lamiaceae) has been studied for the treatment of inflammatory diseases, including dermatologic disorders in Korea. This study examined the effect of salvianolic acid A on AD-like symptoms. Sensitization on the dorsal skin and repeated application on the ears with 2,4-dinitrochlorobenzene (DNCB) were performed in BALB/c mice to induce AD-like skin lesions. After induction of atopic dermatitis, salvianolic acid A (5 and 10 mg/kg) or dexamethasone (10 mg/kg) were administrated via intraperitoneal injection for 3 weeks. Salvianolic acid A suppressed DNCB-induced AD-like symptoms like ear skin hypertrophy and decreased mast cell infiltration into skin lesions. Salvianolic acid A not only reduced DNCB-induced increase of serum IgE but also lowered levels of the Th2 cytokines (IL-4 and IL-13), Th1 cytokine (interferon-γ), and Th17 cytokine (IL-17A). Furthermore, salvianolic acid A blocked DNCB-induced lymph node enlargement. In summary, these results suggest that salvianolic acid A might have a therapeutic potential for the treatment of AD.
- Subjects :
- biology
Article Subject
business.industry
medicine.medical_treatment
Intraperitoneal injection
Atopic dermatitis
Pharmacology
biology.organism_classification
medicine.disease
Salvia miltiorrhiza
BALB/c
Other systems of medicine
medicine.anatomical_structure
Cytokine
Complementary and alternative medicine
medicine
business
Lymph node
RZ201-999
Dexamethasone
Sensitization
medicine.drug
Research Article
Subjects
Details
- ISSN :
- 1741427X
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- Evidence-based complementary and alternative medicine : eCAM
- Accession number :
- edsair.doi.dedup.....6ff175b1ab05b2dc7ff7dc25151aff33