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Analysis of movement-related beta oscillations in the off-medication state during subthalamic nucleus deep brain stimulation surgery
- Publication Year :
- 2019
-
Abstract
- PURPOSE Local field potential recordings from deep brain stimulation (DBS) leads provide insight into the pathophysiology of Parkinson disease (PD). We recorded local field potential activity from DBS leads within the subthalamic nucleus in patients with PD undergoing DBS surgery to identify reproducible pathophysiological signatures of the disease. METHODS Local field potentials were recorded in 11 hemispheres from patients with PD undergoing subthalamic nucleus-DBS. Bipolar recordings were performed off medication for 2 minutes at rest and another 2 minutes with continuous repetitive opening-closing of the contralateral hand. Spectral analysis and bicoherence were performed and compared between the two testing conditions. RESULTS In all hemispheres, predominance of the beta band frequency (13-30 Hz) was observed at rest and during movement. Beta peak energy was significantly (P < 0.05) increased during movement compared with rest in 6 of 10 hemispheres. Significant beta bicoherence was observed at rest and during movement in 5 of 10 hemispheres. The most robust local field potential recordings were observed at the DBS contact(s) independently chosen for programming in 9 of the 10 hemispheres. CONCLUSIONS In patients with PD, beta activity that increases with repetitive movement may be a signature of the "off" medication state. These findings provide new data on beta oscillatory activity during the Parkinsonian "off" state that may help further define the local field potential signatures of PD.
- Subjects :
- Male
medicine.medical_specialty
Deep brain stimulation
Intraoperative Neurophysiological Monitoring
Physiology
medicine.medical_treatment
Deep Brain Stimulation
Movement
Local field potential
050105 experimental psychology
Article
03 medical and health sciences
Beta band
0302 clinical medicine
Subthalamic Nucleus
Physiology (medical)
medicine
Humans
0501 psychology and cognitive sciences
Beta (finance)
Bicoherence
Aged
business.industry
Movement (music)
Subthalamic nucleus deep brain stimulation
05 social sciences
Parkinson Disease
Signal Processing, Computer-Assisted
Middle Aged
Hand
Surgery
Subthalamic nucleus
Neurology
nervous system
Female
Neurology (clinical)
business
Beta Rhythm
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6fefb6310f811c66b770fc1eb443a74f