Additional file 5 of MethCORR infers gene expression from DNA methylation and allows molecular analysis of ten common cancer types using fresh-frozen and formalin-fixed paraffin-embedded tumor samples

Additional file 5: Figure S1. MethCORR inferred RNA expression in ten cancer types. a) Graph showing the inter-sample RNA expression-iRNA expression squared correlations (R2) for BRCA, PRAD, and LUAD validation samples. Genes are ranked according to increasing RNA expression standard deviation in discovery samples. b) Scatterplots with correlations between RNA expression in matched fresh-frozen tissue and FFPE tissue for a representative validation sample from the TCGA BRCA, PRAD, and LUAD cohorts. c) Boxplot with MethCORR and TOBMI [16] validation set 3 inter-sample RNA expression-iRNA expression squared correlations (R2) for overlapping genes between the two methods. Data for all ten cancers are shown. * Wilcoxon rank-sum p