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The Blebbishield Emergency Program Overrides Chromosomal Instability and Phagocytosis Checkpoints in Cancer Stem Cells
- Source :
- Cancer Research. 77:6144-6156
- Publication Year :
- 2017
- Publisher :
- American Association for Cancer Research (AACR), 2017.
-
Abstract
- Genomic instability and immune evasion are hallmarks of cancer. Apoptotic cancer stem cells can evade cell death by undergoing cellular transformation by constructing “blebbishields” from apoptotic bodies. In this study, we report a novel linkage between genomic instability and phagocytosis evasion that is coordinated by the blebbishield emergency program. Blebbishield emergency program evaded genomic instability checkpoint, expressed genomic instability–associated genes at distinct phases of cellular transformation, exhibited chromosomal instability, and promoted increase in nuclear size. Blebbishields fused with immune cells to evade phagocytosis, and the resultant hybrid cells exhibited increased migration, tumorigenesis, metastasis, red blood cell recruitment to tumors, and induced hepatosplenomegaly with signatures of genomic instability, blebbishield emergency program, and phagocytosis evasion to offer poor prognosis. Overall, our data demonstrate that the blebbishield emergency program drives evasion of chromosomal instability and phagocytosis checkpoints by apoptotic cancer stem cells. Cancer Res; 77(22); 6144–56. ©2017 AACR.
- Subjects :
- Male
0301 basic medicine
Genome instability
Cancer Research
Cellular pathology
Transplantation, Heterologous
Mice, Nude
Apoptosis
Biology
medicine.disease_cause
Genomic Instability
03 medical and health sciences
Microscopy, Electron, Transmission
Phagocytosis
Cancer stem cell
Cell Line, Tumor
Neoplasms
Spheroids, Cellular
Chromosome instability
medicine
Animals
Humans
Gene Expression Profiling
Cancer
medicine.disease
Cell biology
Gene Expression Regulation, Neoplastic
Transplantation
Cell Transformation, Neoplastic
030104 developmental biology
Oncology
Neoplastic Stem Cells
Blebbishield emergency program
Carcinogenesis
Subjects
Details
- ISSN :
- 15387445 and 00085472
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Cancer Research
- Accession number :
- edsair.doi.dedup.....6fd8f6520efbc3eaff98315dfb9365c8