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Local ancestry inference in heterogeneous populations—Are recent recombination events more relevant?

Authors :
Marlo Möller
Gian D. van der Spuy
Gerald van Eeden
Caitlin Uren
Gerard Tromp
Source :
Briefings in Bioinformatics. 22
Publication Year :
2021
Publisher :
Oxford University Press (OUP), 2021.

Abstract

To date, numerous software tools have been developed to infer recombination maps. Many of these software tools infer the recombination rate from linkage disequilibrium, and therefore they infer recombination many generations into the past. Other recently developed methods rely on the inference of recent recombination events to determine the recombination rate, such as identity by descent- and local ancestry inference (LAI)-based tools. Methods that mainly use recent recombination events to infer the recombination rate might be more relevant for certain analyses like LAI. We therefore describe a protocol for creating high-resolution, population-specific recombination maps using methods that mainly use recent recombination events and a method that uses recent and distant recombination events for recombination rate inference. Subsequently, we compared the effect of using maps inferred by these two paradigms on LAI accuracy.

Details

ISSN :
14774054 and 14675463
Volume :
22
Database :
OpenAIRE
Journal :
Briefings in Bioinformatics
Accession number :
edsair.doi.dedup.....6fd718097ad1ec86207b508440f09fd0