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Neural correlates of irritability in a community sample of children
- Source :
- Journal of Affective Disorders. 292:223-226
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Irritability has been associated with aberrant patterns of neural activation, yet little is known about structural brain correlates of irritability. As such, we aimed to investigate associations between irritability and gray matter volume (GMV) in a community sample of children enriched for irritability. The sample comprised children (n=162) aged 9-11 years with and without Attention-Deficit/Hyperactivity Disorder (ADHD), participating in a cohort study with magnetic resonance imaging data available. Mixed effects linear regression analyses tested the associations between irritability symptoms and regional GMV (extracted using Freesurfer). Irritability was associated with smaller gray matter volume across multiple brain regions implicated in executive functioning, and emotion and reward processing including frontal regions and the cingulate.
- Subjects :
- Neural correlates of consciousness
business.industry
Brain
Irritability
Magnetic Resonance Imaging
Irritable Mood
030227 psychiatry
Cohort Studies
Reward processing
03 medical and health sciences
Psychiatry and Mental health
Clinical Psychology
0302 clinical medicine
Attention Deficit Disorder with Hyperactivity
Frontal regions
medicine
Mixed effects
Humans
Gray Matter
medicine.symptom
Child
business
030217 neurology & neurosurgery
Clinical psychology
Cohort study
Subjects
Details
- ISSN :
- 01650327
- Volume :
- 292
- Database :
- OpenAIRE
- Journal :
- Journal of Affective Disorders
- Accession number :
- edsair.doi.dedup.....6fc9699024b7a6cfb2bf1840f69c4774