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A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients
- Source :
- EBioMedicine
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Background Although many prognosis-predicting molecular scores for breast cancer have been developed, they are applicable to only limited disease subtypes. We aimed to develop a novel prognostic score that is applicable to a wider range of breast cancer patients. Methods We initially examined The Cancer Genome Atlas breast cancer cohort to identify potential prognosis-related genes. We then performed a meta-analysis of 36 international breast cancer cohorts to validate such genes. We trained artificial intelligence models (random forest and neural network) to predict prognosis precisely, and we finally validated our prediction with the log-rank test. Findings We identified a comprehensive list of 184 prognosis-related genes, most of which have been not extensively studied to date. We then established a universal molecular prognostic score (mPS) that relies on the expression status of only 23 of these genes. The mPS system is almost universally applicable to breast cancer patients (log-rank P
- Subjects :
- Adult
Models, Molecular
0301 basic medicine
Oncology
Scoring system
medicine.medical_specialty
Research paper
MEDLINE
Breast Neoplasms
Kaplan-Meier Estimate
General Biochemistry, Genetics and Molecular Biology
Prognostic score
03 medical and health sciences
Breast cancer
0302 clinical medicine
Internal medicine
Biomarkers, Tumor
medicine
Overall survival
Humans
Precision Medicine
Gene
Aged
Neoplasm Staging
Aged, 80 and over
business.industry
Gene Expression Profiling
General Medicine
Middle Aged
Prognosis
medicine.disease
Personalized medicine
Gene expression profiling
030104 developmental biology
AI
030220 oncology & carcinogenesis
Cohort
Female
Transcriptome
business
Subjects
Details
- ISSN :
- 23523964
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- EBioMedicine
- Accession number :
- edsair.doi.dedup.....6fc844690daceb306796d069e74f54d0