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Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer's disease
- Source :
- Alzheimer's & Dementia. 5:463-469
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Background Alzheimer's disease (AD) patients have been reported to have shorter telomeres in peripheral blood leukocytes (PBLs) than age-matched control subjects. However, it is unclear if PBL telomere length reflects brain telomere length, which might play a more direct role in AD pathogenesis. We examined the correlation between PBL and cerebellum telomere length in AD patients, and compared telomere lengths in cerebella from individuals with AD versus age-matched control subjects. Methods Mean telomere lengths were measured using quantitative telomere polymerase chain reaction of genomic DNA prepared from matched PBL and cerebellum samples from 29 individuals with pathologically confirmed sporadic AD. Telomere length was also measured in cerebellum samples of 30 AD patients versus 22 unaffected age-matched control subjects. Results The PBL and cerebellum telomere lengths were directly correlated in individuals with AD ( r = 0.42, P = 0.023). Nonetheless, cerebellum telomere lengths were not significantly different in AD patients and age-matched control subjects. Conclusions Reduced PBL telomere length in AD might not reflect reduced telomere length in bulk brain tissue, but may be a marker of changes in a subset of brain tissues or other tissues that affect the pathogenesis of AD.
- Subjects :
- Genetic Markers
Male
Aging
Cerebellum
Epidemiology
Longevity
Apoptosis
Disease
Biology
Polymerase Chain Reaction
Sensitivity and Specificity
Article
law.invention
Pathogenesis
Cellular and Molecular Neuroscience
Developmental Neuroscience
Alzheimer Disease
Predictive Value of Tests
Risk Factors
law
Leukocytes
medicine
Humans
Genetic Predisposition to Disease
Cellular Senescence
Polymerase chain reaction
Aged
Aged, 80 and over
Genome, Human
Health Policy
Middle Aged
Telomere
medicine.disease
Psychiatry and Mental health
medicine.anatomical_structure
Genetic marker
Immunology
Female
Neurology (clinical)
Geriatrics and Gerontology
Alzheimer's disease
Cell aging
Subjects
Details
- ISSN :
- 15525279 and 15525260
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia
- Accession number :
- edsair.doi.dedup.....6fb5c33e51c117a53ccb10a325756685