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Gas chromatographic-mass spectrometric determination of chlorophenols in the urine of sawmill workers with past use of chlorophenol-containing anti-stain agents
- Source :
- The Analyst. 120(6)
- Publication Year :
- 1995
-
Abstract
- The aim of this work was to establish whether workers at sawmills where chlorophenol-containing anti-stain agents had been previously used were still exposed to chlorophenols. A gas chromatographic-mass spectrometric (GC-MS) procedure for the determination of chlorophenols in urine was developed. Chlorophenols were determined from hydrolysed urine as acetylated derivatives and determined by GC-MS using selected ion monitoring (SIM). Isolation of the chlorophenols with toluene gave the best extraction efficiencies (65-119%). Stability tests at -20 degrees C showed no degradation of the chlorophenols studied during 6 months. The limit of quantification was 3.6 ng mg-1 creatinine for 2,4,6-trichlorophenol, 5.5 ng mg-1 for 2,3,4,6-tetrachlorophenol and 3.6 ng mg-1 for pentachlorophenol. Traces of 2,4,6-trichlorophenol, 2,3,4,6-tetrachlorophenol and pentachlorophenol were found both in previously exposed workers and in non-exposed controls, the urinary concentrations ranging from 1.1 to 15.9 ng mg-1 creatinine. The concentrations of urinary chlorophenols in previously exposed workers were of the same magnitude as those found in non-exposed controls and in the general population. The results show that it is unlikely that sawmill workers would be currently occupationally exposed to chlorophenols or polychlorinated dibenzo-p-dioxins and dibenzofurans via a contaminated work environment.
- Subjects :
- Male
Population
Urine
Biochemistry
Gas Chromatography-Mass Spectrometry
Analytical Chemistry
chemistry.chemical_compound
Drug Stability
Occupational Exposure
Electrochemistry
Environmental Chemistry
Humans
Selected ion monitoring
education
Spectroscopy
Detection limit
Chlorophenol
education.field_of_study
Chromatography
Chemistry
Hydrolysis
Reproducibility of Results
Acetylation
Contamination
Pentachlorophenol
Cold Temperature
Environmental chemistry
Female
Gas chromatography
Chlorophenols
Toluene
Subjects
Details
- ISSN :
- 00032654
- Volume :
- 120
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The Analyst
- Accession number :
- edsair.doi.dedup.....6fa4b5a87de681a17d0b79177041794f