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Parallel processing by cortical inhibition enables context-dependent behavior
- Source :
- Nature neuroscience
- Publication Year :
- 2016
-
Abstract
- Physical features of sensory stimuli are fixed, but sensory perception is context dependent. The precise mechanisms that govern contextual modulation remain unknown. Here, we trained mice to switch between two contexts: passively listening to pure tones and performing a recognition task for the same stimuli. Two-photon imaging showed that many excitatory neurons in auditory cortex were suppressed during behavior, while some cells became more active. Whole-cell recordings showed that excitatory inputs were affected only modestly by context, but inhibition was more sensitive, with PV+, SOM+, and VIP+ interneurons balancing inhibition and disinhibition within the network. Cholinergic modulation was involved in context switching, with cholinergic axons increasing activity during behavior and directly depolarizing inhibitory cells. Network modeling captured these findings, but only when modulation coincidently drove all three interneuron subtypes, ruling out either inhibition or disinhibition alone as sole mechanism for active engagement. Parallel processing of cholinergic modulation by cortical interneurons therefore enables context-dependent behavior.
- Subjects :
- 0301 basic medicine
Interneuron
Sensory system
Mice, Transgenic
Biology
Auditory cortex
Inhibitory postsynaptic potential
Article
03 medical and health sciences
0302 clinical medicine
medicine
Auditory system
Animals
Visual Cortex
Auditory Cortex
Neurons
Behavior, Animal
General Neuroscience
Neural Inhibition
030104 developmental biology
medicine.anatomical_structure
Disinhibition
Excitatory postsynaptic potential
Auditory Perception
Cholinergic
medicine.symptom
Somatostatin
Neuroscience
030217 neurology & neurosurgery
Vasoactive Intestinal Peptide
Subjects
Details
- Language :
- English
- ISSN :
- 15461726 and 10976256
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature neuroscience
- Accession number :
- edsair.doi.dedup.....6f926fbdb6f84e47a3faf1762bfaeeb5