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Total sleep deprivation combined with lithium and light therapy in the treatment of bipolar depression: replication of main effects and interaction
- Publication Year :
- 2000
-
Abstract
- The clinical usefulness of total sleep deprivation (TSD) in the treatment of bipolar depression is hampered by a high-rate short-term relapse. Previous literature has suggested that both long-term lithium treatment and light therapy could successfully prevent relapse. We randomized 115 bipolar depressed inpatients to receive three cycles of TSD, alone or in combination with morning light exposure, given at an intensity of 150 or 2500 lux. Forty-nine patients were undergoing long-term treatment with lithium salts (at least 6 months), while 66 patients were taking no psychotropic medication. Mood was self-rated by the Visual Analogue Scale three times a day during treatment. The results showed that both light therapy and ongoing lithium treatment significantly enhanced the effects of TSD on the perceived mood, with no additional benefit when the two treatments were combined. Subjective sleepiness during TSD, as rated by the self-administered Stanford Sleepiness Scale, was significantly reduced by light exposure, and was correlated with the outcome. This study confirms the possibility of obtaining a sustained antidepressant response to TSD in bipolar patients. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
- Subjects :
- Light therapy
Adult
Male
endocrine system
medicine.medical_specialty
Bipolar Disorder
Lithium (medication)
Visual analogue scale
medicine.drug_class
medicine.medical_treatment
Wake therapy
Lithium Carbonate
Antimanic Agents
Internal medicine
medicine
Humans
Bipolar disorder
Psychiatry
Biological Psychiatry
Aged
Psychiatric Status Rating Scales
Depressive Disorder
Mood stabilizer
Middle Aged
Phototherapy
medicine.disease
Combined Modality Therapy
Psychiatry and Mental health
Sleep deprivation
Mood
Sleep Deprivation
Female
medicine.symptom
Psychology
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6f7b4c0bc2c8727bad79c5cec9189a25