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Caesarean delivery and pubertal timing in boys and girls:A Danish population-based cohort study
- Source :
- Huang, K, Gaml-Sørensen, A, Lunddorf, L L H, Ernst, A, Brix, N, Olsen, J & Ramlau-Hansen, C H 2022, ' Caesarean delivery and pubertal timing in boys and girls : A Danish population-based cohort study ', Paediatric and Perinatal Epidemiology, vol. 36, no. 1, 12827, pp. 104-112 . https://doi.org/10.1111/ppe.12827
- Publication Year :
- 2022
-
Abstract
- BACKGROUND: There is considerable public and scientific interest in the declining age of pubertal timing. Prenatal and postnatal stress has been proposed to relate with earlier pubertal timing, but it remains unknown whether intrapartum stress may affect pubertal timing as well.OBJECTIVE: This study aims to examine the potential effect of caesarean delivery on pubertal timing in boys and girls.METHODS: This study was based upon the nationwide Puberty Cohort nested within the Danish National Birth Cohort (DNBC) from 2000 to 2003. A total of 15,731 mother-child pairs with complete information on delivery mode and puberty were included in the main analysis. The delivery mode was categorised into non-instrumental vaginal delivery (reference), instrumental vaginal delivery, elective caesarean delivery before labour, emergency caesarean delivery during labour and un-specified caesarean delivery. Children's pubertal development were self-reported in web-based questionnaires from 11 years of age and every 6 months throughout puberty (2012-2019), including Tanner stages 2-5, menarche, voice break, first ejaculation, axillary hair growth and the onset of acne. Regression models for censored, normally distributed time-to-event data were used to estimate mean monthly differences in age at attaining the different pubertal milestones and the average of all these estimates for each sex (a combined indicator of pubertal timing).RESULTS: A total of 2810 participants were born by caesarean delivery (17.9%). Neither elective nor emergency caesarean delivery was associated with earlier age at achieving the pubertal milestones in boys or in girls. For the combined indicator, the mean age differences for elective caesarean delivery and emergency caesarean delivery were 0.1 (95% CI -1.1, 1.4) months and -0.7 (95% CI -2.0, 0.5) months in boys and 0.7 (95% CI -0.7, 2.0) and 0.2 (95% CI -1.3, 1.7) in girls.CONCLUSIONS: This study does not suggest a clinically important effect of caesarean delivery on children's pubertal timing.
- Subjects :
- Male
medicine.medical_specialty
puberty
Epidemiology
Ejaculation
Denmark
Caesarean delivery
Danish
Cohort Studies
birth stress
Pregnancy
cohort study
Medicine
Humans
business.industry
Vaginal delivery
Obstetrics
Cesarean Section
Puberty
Infant, Newborn
Delivery mode
sexual maturation
language.human_language
Pediatrics, Perinatology and Child Health
Cohort
language
Menarche
Birth Cohort
Female
caesarean delivery
business
Cohort study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Huang, K, Gaml-Sørensen, A, Lunddorf, L L H, Ernst, A, Brix, N, Olsen, J & Ramlau-Hansen, C H 2022, ' Caesarean delivery and pubertal timing in boys and girls : A Danish population-based cohort study ', Paediatric and Perinatal Epidemiology, vol. 36, no. 1, 12827, pp. 104-112 . https://doi.org/10.1111/ppe.12827
- Accession number :
- edsair.doi.dedup.....6f7ab7d9d2e18fe70815cc15c9f3f04d