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Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum
- Source :
- PLoS ONE, Vol 13, Iss 11, p e0206934 (2018), PLoS ONE
- Publication Year :
- 2018
- Publisher :
- Public Library of Science (PLoS), 2018.
-
Abstract
- Epidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation and oxidative stress. This study examined the effect of nano-sized particulate matter (nPM) on complement C5 deposition and microglial activation in the corpus callosum of mice (C57BL/6J males). nPM was collected in an urban Los Angeles region impacted by traffic emissions. Mice were exposed to 10 weeks of re-aerosolized nPM or filtered air for a cumulative 150 hours. nPM-exposed mice exhibited reactive microglia and 2-fold increased local deposition of complement C5/ C5α proteins and complement component C5a receptor 1 (CD88) in the corpus callosum. However, serum C5 levels did not differ between nPM and filtered air cohorts. These findings demonstrate white matter C5 deposition and microglial activation secondary to nPM exposure. The C5 upregulation appears to be localized to the brain.
- Subjects :
- Central Nervous System
0301 basic medicine
Physiology
Complement System
Complement receptor
Corpus callosum
medicine.disease_cause
Nervous System
Biochemistry
Immune Receptors
C5a receptor
Corpus Callosum
Mice
0302 clinical medicine
Animal Cells
Immune Physiology
Medicine and Health Sciences
Materials
Staining
Complement component 5
Immune System Proteins
Multidisciplinary
Microglia
integumentary system
Complement C5
Brain
Complement Receptors
Pollution
Specimen preparation and treatment
Particulates
medicine.anatomical_structure
Physical Sciences
Medicine
Anatomy
Cellular Types
Research Article
Signal Transduction
medicine.medical_specialty
Science
Immunology
Materials Science
Neurocognitive Disorders
Glial Cells
Biology
White matter
03 medical and health sciences
Air Pollution
Internal medicine
medicine
Animals
Humans
Microglial Cells
Neuroinflammation
Inflammation
Ecology and Environmental Sciences
DAPI staining
Biology and Life Sciences
Proteins
Cell Biology
Research and analysis methods
Oxidative Stress
030104 developmental biology
Endocrinology
13. Climate action
Immune System
Mixtures
Nuclear staining
Nanoparticles
Particulate Matter
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....6f62cba8105acc42443409a562632c1b