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Involvement of cannabinoid receptors in the amygdala and prefrontal cortex of rats in fear learning, consolidation, retrieval and extinction
- Source :
- Behavioural Brain Research. 250:274-284
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Cannabinoid receptors 1 (CB1R) have been shown to be a crucial part of the neuromodulatory endocannabinoid system which is involved in emotional learning and memory. We here investigated in rats the role of CB1R in the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC) in different phases of fear learning, memory and extinction. We used the fear potentiated startle paradigm to measure the effects of local microinfusion of the CB1R agonist WIN 55,212-2 (WIN) or the CB1R antagonist AM251 on acquisition, consolidation, retrieval and extinction of fear. No effects on fear acquisition of WIN or AM251 were found in the BLA or mPFC. WIN impaired fear retrieval in the BLA and in mPFC. Also, WIN reduced fear consolidation in the BLA but not in the mPFC. AM251 decreased fear consolidation after mPFC infusion. Likewise, fear extinction was impaired by AM251 infused into the mPFC. Our data indicate that fear memory consolidation and retrieval, as well as extinction are regulated differentially by amygdaloid and cortical CB1R.
- Subjects :
- Male
AM251
Microinjections
Morpholines
Prefrontal Cortex
Naphthalenes
Amygdala
Fear-potentiated startle
Extinction, Psychological
Behavioral Neuroscience
Piperidines
Receptor, Cannabinoid, CB1
Conditioning, Psychological
medicine
Animals
Rats, Wistar
Prefrontal cortex
WIN 55,212-2
Fear processing in the brain
Analysis of Variance
musculoskeletal, neural, and ocular physiology
Fear
Extinction (psychology)
humanities
Benzoxazines
Rats
medicine.anatomical_structure
nervous system
Mental Recall
behavior and behavior mechanisms
Pyrazoles
Psychology
Neuroscience
psychological phenomena and processes
Basolateral amygdala
medicine.drug
Subjects
Details
- ISSN :
- 01664328
- Volume :
- 250
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....6f4108714942a19622ef6420e15b6684