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Renal failure associated with intestinal transplantation: our experience in Spain
- Source :
- Transplantation proceedings. 46(6)
- Publication Year :
- 2014
-
Abstract
- Background Renal failure (RF) is a frequent complication in non-renal solid organ transplants. In the present study, we analyze our experience with intestinal transplants (ITx). Methods Between 2004 and 2012, we performed 21 ITx in 19 adult patients. Alemtuzumab was used as an induction agent followed by tacrolimus. Renal function was assessed before ITx and during the perioperative period. Results The main cause for transplants was non-resectable desmoids tumors (33.3%), followed by vascular thrombosis (19%) and others. Medical complications were frequent, especially infectious diseases, which were the most common (51%). Surgical complications were also frequent, but most of them (>50%) were mild but leading to a great number of re-operations and prolonged stays in hospital. Acute rejection is very frequent (66.6%) but mild in more than 70% of the cases. Finally, RF was very frequent (68.4%; 13/19 patients) and accounted for 15.6% of all medical complications. Causes were multiple. One patient is awaiting a kidney transplant, but no other patients need renal replacement therapy at the moment. Ileostomy closure was performed in 5 of 12 patients alive, showing improved renal function in 3 of them. Conclusions RF is a problem in ITx and is always multifactorial. Increases in hospital stay, higher morbidity and is a cause for hospital readmission. Almost all patients had an impaired renal function when discharged. Immunosuppressants and ileostomy closure as soon as possible might prevent RF.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Renal function
Organ transplantation
Very frequent
Young Adult
Intestine, Small
Medicine
Humans
Renal replacement therapy
Renal Insufficiency
Retrospective Studies
Transplantation
business.industry
Incidence
Perioperative
Organ Transplantation
Middle Aged
Surgery
Intestinal Diseases
Spain
Alemtuzumab
Female
business
Complication
medicine.drug
Subjects
Details
- ISSN :
- 18732623
- Volume :
- 46
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Transplantation proceedings
- Accession number :
- edsair.doi.dedup.....6f3bf465be5724217ec817b24ce9bfec