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Effects of phlebotomy therapy on cytochrome P450 2e1 activity and oxidative stress markers in dysmetabolic iron overload syndrome: a randomized trial
- Source :
- Alimentary Pharmacology and Therapeutics, Alimentary Pharmacology and Therapeutics, 2006, 24 (8), pp.1207-13. ⟨10.1111/j.1365-2036.2006.03116.x⟩, Alimentary Pharmacology and Therapeutics, Wiley, 2006, 24 (8), pp.1207-13. ⟨10.1111/j.1365-2036.2006.03116.x⟩
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- International audience; AIM: To assess the effects of iron removal on cytochrome P450 2E1 activity and oxidative stress in dysmetabolic iron overload syndrome. METHODS: Forty-eight patients were randomized to phlebotomy therapy consisting of removal of 300-500 mL of blood every 14 days until serum ferritin levels dropped under 100 microg/L or to follow-up without phlebotomy therapy. Cytochrome P450 2E1 activity was measured at baseline and at the end of treatment by using the 6-hydroxychlorzoxazone/chlorzoxazone blood metabolic ratio, 2 h after the intake of 500 mg of chlorzoxazone. RESULTS: In the treatment group, a mean of 3.9 +/- 1.3 L of blood was removed and serum ferritin levels dropped from 715 +/- 397 to 74 +/- 34 microg/L. Variation of cytochrome P450 2E1 activity was not significantly different between the 2 groups (0.07 +/- 0.26 vs. 0.03 +/- 0.19, P = 0.36). In the treatment group, low-density lipoprotein cholesterol and vitamin E were lowered after treatment compared with control group (-0.15 +/- 0.51 vs. 0.24 +/- 0.58, P = 0.002 and -1.3 +/- 4.4 vs. 2.3 +/- 5.2, P = 0.03, respectively). Inversely, vitamin C was increased (0.5 +/- 3.5 vs. -1.8 +/- 3.9, P = 0.03). CONCLUSIONS: In dysmetabolic iron overload syndrome, reduction of iron stores does not significantly influence cytochrome P450 2E1 activity but is associated with a significant decrease of low-density lipoprotein cholesterol, suggesting that venesection therapy may be a suitable option in these patients.
- Subjects :
- Male
medicine.medical_treatment
Ascorbic Acid
medicine.disease_cause
law.invention
chemistry.chemical_compound
MESH: Vitamin E
0302 clinical medicine
Phlebotomy
Randomized controlled trial
law
Malondialdehyde
Vitamin E
MESH: Ascorbic Acid
Medicine
Pharmacology (medical)
Prospective Studies
MESH: Oxidative Stress
Gastroenterology
Cytochrome P-450 CYP2E1
CYP2E1
3. Good health
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
030220 oncology & carcinogenesis
Chlorzoxazone
030211 gastroenterology & hepatology
MESH: Cholesterol, LDL
medicine.drug
medicine.medical_specialty
Iron Overload
MESH: Malondialdehyde
MESH: Ferritins
MESH: Iron Overload
03 medical and health sciences
Internal medicine
Humans
MESH: Humans
Hepatology
Vitamin C
Cholesterol
business.industry
MESH: Biological Markers
Cholesterol, LDL
MESH: Prospective Studies
MESH: Male
Oxidative Stress
MESH: Phlebotomy
Endocrinology
chemistry
MESH: Cytochrome P-450 CYP2E1
Ferritins
business
Biomarkers
Oxidative stress
Subjects
Details
- ISSN :
- 13652036 and 02692813
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Alimentary Pharmacology and Therapeutics
- Accession number :
- edsair.doi.dedup.....6f33444d15d37431a958e803a6332ed6