Back to Search Start Over

Presence of Phosphorylcholine on a Filarial Nematode Protein Influences Immunoglobulin G Subclass Response to the Molecule by an Interleukin-10-Dependent Mechanism

Presence of Phosphorylcholine on a Filarial Nematode Protein Influences Immunoglobulin G Subclass Response to the Molecule by an Interleukin-10-Dependent Mechanism

Authors :
William Harnett
Emma H. Wilson
James Alexander
Frank Brombacher
Margaret M. Harnett
Katrina M. Houston
Linda Eyres
Source :
Infection and Immunity. 68:5466-5468
Publication Year :
2000
Publisher :
American Society for Microbiology, 2000.

Abstract

The filarial nematode product ES-62 contains phosphorylcholine (PC) covalently attached to N-linked glycans. ES-62 induced high levels of immunoglobulin G1 (IgG1) antibodies, but no IgG2a, to non-PC epitopes of the molecule following subcutaneous injection into BALB/c mice. Conversely, mice given ES-62 lacking PC demonstrated significant production of both IgG subclasses. Thus, PC appears to block production of IgG2a antibodies to other epitopes on the parasite molecule. A role for interleukin-10 (IL-10) in this effect was shown by the ability of IL-10−/−mice to make an IgG2a antibody response to non-PC epitopes of ES-62.

Details

ISSN :
10985522 and 00199567
Volume :
68
Database :
OpenAIRE
Journal :
Infection and Immunity
Accession number :
edsair.doi.dedup.....6f245150fd4e021ecb20c28b29381ce5
Full Text :
https://doi.org/10.1128/iai.68.9.5466-5468.2000