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Presence of Phosphorylcholine on a Filarial Nematode Protein Influences Immunoglobulin G Subclass Response to the Molecule by an Interleukin-10-Dependent Mechanism
Presence of Phosphorylcholine on a Filarial Nematode Protein Influences Immunoglobulin G Subclass Response to the Molecule by an Interleukin-10-Dependent Mechanism
- Source :
- Infection and Immunity. 68:5466-5468
- Publication Year :
- 2000
- Publisher :
- American Society for Microbiology, 2000.
-
Abstract
- The filarial nematode product ES-62 contains phosphorylcholine (PC) covalently attached to N-linked glycans. ES-62 induced high levels of immunoglobulin G1 (IgG1) antibodies, but no IgG2a, to non-PC epitopes of the molecule following subcutaneous injection into BALB/c mice. Conversely, mice given ES-62 lacking PC demonstrated significant production of both IgG subclasses. Thus, PC appears to block production of IgG2a antibodies to other epitopes on the parasite molecule. A role for interleukin-10 (IL-10) in this effect was shown by the ability of IL-10−/−mice to make an IgG2a antibody response to non-PC epitopes of ES-62.
- Subjects :
- Phosphorylcholine
Immunology
Antibodies, Helminth
Microbiology
Immunoglobulin G
Epitope
Mice
Antigen
Animals
Filarioidea
Interleukin 4
Mice, Inbred BALB C
biology
Interleukin
Molecular biology
Isotype
Interleukin-10
Infectious Diseases
biology.protein
Parasitology
Interleukin-4
Fungal and Parasitic Infections
Antibody
Subjects
Details
- ISSN :
- 10985522 and 00199567
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Infection and Immunity
- Accession number :
- edsair.doi.dedup.....6f245150fd4e021ecb20c28b29381ce5
- Full Text :
- https://doi.org/10.1128/iai.68.9.5466-5468.2000