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The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas
- Source :
- Cancer cell. 4(5)
- Publication Year :
- 2003
-
Abstract
- By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC.
- Subjects :
- Cancer Research
Positional cloning
Cell Adhesion Molecules, Neuronal
Cell
Molecular Sequence Data
Biology
GPI-Linked Proteins
medicine
Animals
Humans
Cloning, Molecular
Carcinoma, Renal Cell
Cells, Cultured
Adaptor Proteins, Signal Transducing
Monomeric GTP-Binding Proteins
Base Sequence
Cell growth
Breakpoint
Cell Biology
Methylation
DNA Methylation
medicine.disease
Molecular biology
Gene Expression Regulation, Neoplastic
Clear cell renal cell carcinoma
medicine.anatomical_structure
Oncology
Cell culture
Apoptosis Regulatory Proteins
Clear cell
Cell Division
Adenocarcinoma, Clear Cell
Subjects
Details
- ISSN :
- 15356108
- Volume :
- 4
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cancer cell
- Accession number :
- edsair.doi.dedup.....6f21c8418dde5fd0c75901e94ae99417